3-溴-2-吡啶甲酸甲酯合成路线 （共 12 条）
反应条件
sulfuric acid in methanol T=20°C; 12 h;
参考文献
Shinogi and Co., Ltd.
Patent: US2011/136833 A1, 2011 ;
Location in patent: Page/Page column 27 ;
反应条件
1: 3-bromo-2-pyridinecarboxylic acid With sodium hydride in DMF (N,N-dimethyl-formamide) T=0°C; 0.833333 h; 2: methyl iodide in DMF (N,N-dimethyl-formamide) T=0 - 20°C; 48 h;
参考文献
Ladduwahetty, Tamara; MacLeod, Angus Murray; Merchant, Kevin John; Sternfeld, Francine
Patent: US2004/6226 A1, 2004 ;
Location in patent: Page 11 ;
反应条件
1: in methanol T=20 - 70°C; 4 h; 2: With water; hydrogenchloride in methanol T=20°C; 4 h;
参考文献
EP1726590 A1, ;
Page/Page column 85 ;
反应条件
thionyl chloride T=0 - 85°C; 24 h;
参考文献
Penning, Miriam; Christoffers, Jens
European Journal of Organic Chemistry, 2014 , vol. 2014, # 10 p. 2140 - 2149
反应条件
sodium hydroxide in methanol
参考文献
Sanofi Winthrop Inc.
Patent: US5556909 A1, 1996 ;
US 5556909 A
反应条件
1: With sulfuric acid T=90°C; 2: With sodium hydrogencarbonate in water Product distribution / selectivity;
参考文献
US2010/69425 A1, ;
Page/Page column 13 ;
反应条件
3 h; Heating / reflux;
参考文献
WO2006/95205 A1, ;
Page/Page column 21-22 ;
WO 2006/095205 A1
反应条件
1: 1.) n-BuLi, 2.) substituted 1,2-dibromoethane / 1.) THF, -78 deg C - 0.5 h, room temperature - 1 h, 2.) THF, -78 deg C - 1 h, room temperature - 2 h 2: aq. HCl / 15 h / Heating 3: 1.) aq. NaHCO3 / 2.) DMF, 0 deg C, 4 h View Scheme
参考文献
Synthetic Communications, , vol. 27, # 6 p. 1075 - 1086
反应条件
1: aq. HCl / 15 h / Heating 2: 1.) aq. NaHCO3 / 2.) DMF, 0 deg C, 4 h View Scheme
参考文献
Synthetic Communications, , vol. 27, # 6 p. 1075 - 1086
反应条件
methanol; sodium tetrahydroborate T=0 - 20°C;
参考文献
TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; BOHNERT, Gary, J.; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; SUNG, Leonard
Patent: WO2013/19682 A1, 2013 ;
Location in patent: Page/Page column 97 ;
WO 2013/019682 A1
