1-(2-氨基-3-甲基苯基)乙酮合成路线 （共 8 条）
反应条件
1: With boron trichloride in toluene
T=20°C; Addition; 1 h;
2: With aluminium trichloride in acetonitrile
Rearrangement; 5 h; Heating;
3: With hydrogenchloride in acetonitrile
Hydrolysis; 2.5 h; Heating;
参考文献
Tabuchi, Seiichiro; Ito, Harunobu; Sogabe, Hajime; Kuno, Masako; Kinoshita, Takayoshi; Katumi, Ikuyo; Yamamoto, Naoko; Mitsui, Hitoshi; Satoh, Yoshinari
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 1 p. 1 - 15
反应条件
hydrogenchloride; sulfuric acid in ethanol; water
参考文献
Chevron Research Company
Patent: US4244730 A1, 1981 ;
反应条件
in ethylene glycol dimethyl ether; ethylene glycol diethyl ether
T=0°C; 2 h; Inert atmosphere;
参考文献
Mangas-Sanchez, Juan; Busto, Eduardo; Gotor-Fernandez, Vicente; Gotor, Vicente
Organic Letters, 2012 , vol. 14, # 6 p. 1444 - 1447
反应条件
hydrogenchloride in methanol; ethanol; water
参考文献
Sumitomo Chemical Company, Limited
Patent: US4032573 A1, 1977 ;
反应条件
hydrogenchloride; tin
Heating;
参考文献
Doppler,T. et al.
Helvetica Chimica Acta, 1979 , vol. 62, p. 271 - 303
反应条件
1: (i) Mg, Et2O, (ii) /BRN= 2265236/, Et2O, (iii) aq. H2SO4, AcOH
2: Sn, aq. HCl / Heating
View Scheme
参考文献
Doppler,T. et al.
Helvetica Chimica Acta, 1979 , vol. 62, p. 271 - 303
反应条件
T=20 - 25°C; 24 h; Irradiationon silica gel; Yield given;
参考文献
Magdy, M.; Malik, Abdel-; Mayo, Paul de
Canadian Journal of Chemistry, 1984 , vol. 62, p. 1275 - 1278
反应条件
1: concentrated HCl / Diazotization
2: POCl3; PCl5
3: <NH4>2 CO3
View Scheme
参考文献
Keneford et al.
Journal of the Chemical Society, 1948 , p. 1702,1706
