3-甲基-4-硝基苯甲醚合成路线 （共 58 条）
反应条件
1: N-bromosuccinimide (NBS), azoisobutyronitrile (AIBN) / CCl4 / 3 h / Heating 2: toluene / 1.) 6 h, RT; 2.) 3 h, 100 deg C 3: 74 percent / 48percent HBr, Zn / ethanol / 2 h / Heating 4: 92 percent / pyridine / CH2Cl2 / 1 h / Heating 5: 97 percent / t-BuOK / toluene / 0.25 h / Heating View Scheme
参考文献
Corre, M. Le; Hercouet, A.; Stanc, Y. Le; Baron, H. Le
Tetrahedron, 1985 , vol. 41, # 22 p. 5313 - 5320
反应条件
hydrogen; platinum(IV) oxide in isopropyl alcohol P=2327.2 Torr;
参考文献
Young, David C.; Vouros, Paul; Holick, Michael F.; Higuchi, Tetsuo
Analytical Chemistry, 1992 , vol. 64, # 8 p. 837 - 842
反应条件
1: 34 percent / KMnO4, pyridine / H2O / 6 h / Heating 2: 97.5 percent / H2 / 10percent Pd/C / ethyl acetate / 1 h / 760 Torr / Ambient temperature View Scheme
参考文献
Pavlidis; Perry
Synthetic Communications, 1994 , vol. 24, # 4 p. 533 - 548
反应条件
1: 98.5 percent / H2 / PtO2 / propan-2-ol / 2327.2 Torr 2: 1) conc. H2SO4, NaNO2, 2) CuBr, HBr / 1) H2O, 0-10 deg C, 2) H2O 3: 1) n-BuLi / 1) pentane, 5 psi, 6 h, 2) pentane, THF, 30 min View Scheme
参考文献
Young, David C.; Vouros, Paul; Holick, Michael F.; Higuchi, Tetsuo
Analytical Chemistry, 1992 , vol. 64, # 8 p. 837 - 842
反应条件
1: 2.) hydrazine hydrate / 2.) Raney nickel / 1.) reflux, 3 h, 2.) THF, MeOH, RT, 30 min 2: 1.) phosphorus oxychloride, 2.) conc. HCl / 1.) 0 deg C, 1 h, 2.) MeOH, THF, RT, 45 min View Scheme
参考文献
Buchheit; Gamse; Giger; Hoyer; Klein; Kloeppner; Pfannkuche; Mattes
Journal of medicinal chemistry, 1995 , vol. 38, # 13 p. 2331 - 2338
反应条件
1: 2.89 g / 7 h / 148 - 150 °C 2: 72 percent / H2 / Pd/C / benzene / 8 h / 50 °C / 4560 Torr View Scheme
参考文献
Gribble, Gordon W.; Saulnier, Mark G.; Obaza-Nutaitis, Judy A.; Ketcha, Daniel M.
Journal of Organic Chemistry, 1992 , vol. 57, # 22 p. 5891 - 5899
反应条件
hydrazine hydrate; nickel 1.) reflux, 3 h, 2.) THF, MeOH, RT, 30 min; Multistep reaction;
参考文献
Buchheit; Gamse; Giger; Hoyer; Klein; Kloeppner; Pfannkuche; Mattes
Journal of medicinal chemistry, 1995 , vol. 38, # 13 p. 2331 - 2338
反应条件
1: With pyrrolidine in N,N-dimethyl-formamide T=110°C; Leimgruber-Batcho indole synthesis; 5 h; Inert atmosphere; 2: With FeCl3·6H2O; carbon; hydrazine hydrate in ethanol T=75°C; Leimgruber-Batcho indole synthesis; 5 h;
参考文献
Taydakov; Dutova; Sidorenko; Krasnoselsky
Chemistry of Heterocyclic Compounds, 2011 , vol. 47, # 4 p. 425 - 434
反应条件
iron; silica gel 1) 120 deg C, 4 h, under vacuum 2) 1 h reflux in toluene-acetic acid; Yield given. Multistep reaction;
参考文献
Kawase, Masami; Sinhababu, Achintya K.; Borchardt, Ronald T.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 1499 - 1501
反应条件
sodium hydroxide; tert-butyl alcohol in water Irradiation; Quantum yield;
参考文献
Sawaura, Masaki; Mukai, Toshio
Bulletin of the Chemical Society of Japan, 1981 , vol. 54, # 10 p. 3213 - 3214
