3-甲基-4-硝基苯甲醚合成路线 （共 58 条）
反应条件
acetic acid in C6H5Cl
参考文献
Massachusetts Institute of Technology
Patent: US7399639 B2, 2008 ;
反应条件
tetrachloromethane; N-bromosuccinmide; dibenzoyl peroxide
参考文献
Celnik,K.; Jankowski,Z.
Polish Journal of Chemistry, 1978 , vol. 52, p. 947 - 951
参考文献
Marion
Journal of the American Chemical Society, 1944 , vol. 66, p. 1125
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Faltis et al.
Chemische Berichte, 1944 , vol. 77/79, p. 686,694
参考文献
Reissert; Scherk
Chemische Berichte, 1898 , vol. 31, p. 394
反应条件
1: 1) SnCl*2H2O, conc. HCl; 2) pyridine / 1) ethanol, reflux, 6 h; 2) heating, 2 h.
2: 1) KMnO4; 2) conc. HCl
3: 50 percent / POCl3 / 1 h / Heating
4: 1) 47percent HBr, 2) 10percent KOH / 1) reflux, 5 h
View Scheme
参考文献
Karimov, A.; Telezhenetskaya, M. V.; Yunusov, S. Yu.
Chemistry of Natural Compounds, 1982 , vol. 18, # 4 p. 466 - 472
Khimiya Prirodnykh Soedinenii, 1982 , vol. 18, # 4 p. 498 - 504
反应条件
N-bromosuccinmide in acetonitrile
T=140°C; Sealed tube;
参考文献
PFIZER INC.
Patent: US2012/270893 A1, 2012 ;
Location in patent: Page/Page column 32 ;
反应条件
1: dimethylformamide / 21 h / Heating
2: 68 percent / H2 / 5percent Pd/C / benzene / 27 h / 25 °C / 2280 Torr
3: 1.) 1.65 M n-BuLi / 1.) THF, hexane, -75 deg C to 0 deg C, 45 min, 2.) -75 deg C to r.t., overnight
View Scheme
参考文献
Gribble, Gordon W.; Saulnier, Mark G.; Obaza-Nutaitis, Judy A.; Ketcha, Daniel M.
Journal of Organic Chemistry, 1992 , vol. 57, # 22 p. 5891 - 5899
反应条件
1: tin; hydrochloric acid
2: NaOH-solution
View Scheme
参考文献
Ruggli; Leonhardt
Helvetica Chimica Acta, 1924 , vol. 7, p. 698
