1-(4-氨基-3-氟苯基)吡啶-2(1h)-酮合成路线 （共 6 条）
反应条件
copper(l) iodide; 8-hydroxy-quinoline; caesium carbonate in 1,4-dioxane; dimethyl sulfoxide
T=120°C;
参考文献
MILLENNIUM PHARMACEUTICALS, INC.; SCARBOROUGH, Carroll
Patent: WO2008/86226 A2, 2008 ;
Location in patent: Page/Page column 87 ;
WO 2008/086226 A2
反应条件
hydrogen; palladium on activated carbon in methanol; ethyl acetate
T=20°C; P=760.051 Torr; Product distribution / selectivity;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2008/77797 A1, 2008 ;
Location in patent: Page/Page column 27; 43-44 ;
反应条件
1: With tin(ll) chloride in ethanol
0.75 h; Heating / reflux;
2: With sodium hydroxide; water in ethyl acetate
参考文献
Boehringer Ingelheim International GmbH
Patent: US2006/142263 A1, 2006 ;
Location in patent: Page/Page column 49 ;
反应条件
potassium phosphate; copper(l) iodide; trans-1,2diaminocyclohexane in 1,4-dioxane
22 h; Heating / reflux;
参考文献
WARNER-LAMBERT COMPANY LLC
Patent: WO2006/100565 A1, 2006 ;
Location in patent: Page/Page column 15 ;
WO 2006/100565 A1
反应条件
copper(I) oxide; potassium carbonate; N-methyl-2-(methylamino)ethylamine in toluene
16 h; Heating / reflux; Product distribution / selectivity;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2008/77797 A1, 2008 ;
Location in patent: Page/Page column 4; 41 ;
反应条件
CuI; potassium carbonate in dimethyl sulfoxide; ethyl acetate
参考文献
Bigge, Christopher Franklin; Casimiro-Garcia, Agustin; Dudley, Danette Andrea; Edmunds, Jeremy John; Filipski, Kevin James; Kohrt, Jeffrey Thomas; Van Huis, Chad Alan
Patent: US2003/162787 A1, 2003 ;
