N-(4-氯-2-氟苄基)邻苯二甲酰亚胺合成路线 （共 4 条）
反应条件
hydrazine in tetrahydrofuran T=80°C; 1 h;
参考文献
Leonard, Kristi; Marugan, Juan Jose; Raboisson, Pierre; Calvo, Raul; Gushue, Joan M.; Koblish, Holly K.; Lattanze, Jennifer; Zhao, Shuyuan; Cummings, Maxwell D.; Player, Mark R.; Maroney, Anna C.; Lu, Tianbao
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 13 p. 3463 - 3468
反应条件
in DMF (N,N-dimethyl-formamide)
T=20°C; 2 h;
参考文献
Sumitomo Chemical Company, Limited
Patent: EP1577290 A1, 2005 ;
Location in patent: Page/Page column 108 ;
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran
T=20°C; Mitsunobu reaction; 3 h;
参考文献
Leonard, Kristi; Marugan, Juan Jose; Raboisson, Pierre; Calvo, Raul; Gushue, Joan M.; Koblish, Holly K.; Lattanze, Jennifer; Zhao, Shuyuan; Cummings, Maxwell D.; Player, Mark R.; Maroney, Anna C.; Lu, Tianbao
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 13 p. 3463 - 3468
反应条件
1: NaBH4 / tetrahydrofuran / 1 h / 20 °C
2: Ph3P; DIAD / tetrahydrofuran / 3 h / 20 °C
View Scheme
参考文献
Leonard, Kristi; Marugan, Juan Jose; Raboisson, Pierre; Calvo, Raul; Gushue, Joan M.; Koblish, Holly K.; Lattanze, Jennifer; Zhao, Shuyuan; Cummings, Maxwell D.; Player, Mark R.; Maroney, Anna C.; Lu, Tianbao
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 13 p. 3463 - 3468
