3-(4-氧代-3,4-二氢-2-喹唑啉)-丙酸合成路线 （共 7 条）
反应条件
in toluene 4 h; Heating;
参考文献
Usifoh
Scientia Pharmaceutica, 2000 , vol. 68, # 3 p. 275 - 279
反应条件
sodium acetate; acetic anhydride 0.5 h; Heating;
参考文献
AMGEN INC.; BREGMAN, Howard; BUCHANAN, John L.; CHAKKA, Nagasree; DIMAURO, Erin F.; GUNAYDIN, Hakan; GUZMAN PEREZ, Angel; HUA, Zihao; HUANG, Xin
Patent: WO2014/36022 A1, 2014 ;
Location in patent: Paragraph 0209-0210 ;
反应条件
formamide T=190°C; 3 h;
参考文献
Essawy, A.; El-Hashash, M. A.; El-Gendy, A. M.; Hamad, M. M. M.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 6 p. 593 - 595
反应条件
urea hydrogen peroxide addition compound; potassium carbonate in water; acetone
参考文献
Lindgren, Anders E.G.; Karlberg, Tobias; Ekblad, Torun; Spjut, Sara; Thorsell, Ann-Gerd; Andersson, C. David; Nhan, Ton Tong; Hellsten, Victor; Weigelt, Johan; Linusson, Anna; Schueler, Herwig; Elofsson, Mikael
Journal of Medicinal Chemistry, 2013 , vol. 56, # 23 p. 9556 - 9568
反应条件
1: 91 percent / acetic acid / 0.5 h 2: 78 percent / sodium acetate / acetic anhydride / 0.25 h / Heating View Scheme
参考文献
Russian Journal of Organic Chemistry, , vol. 42, # 3 p. 382 - 387
反应条件
1: toluene 2: potassium carbonate; urea hydrogen peroxide addition compound / acetone; water View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 56, # 23 p. 9556 - 9568
反应条件
sodium acetate in acetic anhydride
0.5 h; Heating;
参考文献
Shemchuk; Chernykh; Krys'kiv
Russian Journal of Organic Chemistry, 2006 , vol. 42, # 3 p. 382 - 387
