6-氨基-1-丁基-1H-嘧啶-2,4-二酮合成路线 （共 9 条）
反应条件
aqueous hydrochloric acid in ethanol; water
参考文献
Dunten, Peter W.; Foley, Louise H.; Huby, Nicholas J.S.; Pietranico-Cole, Sherrie L.; Yun, Weiya
Patent: US2004/14766 A1, 2004 ;
反应条件
sodium hydroxide; acetic anhydride in water
参考文献
Aktiebolaget Draco
Patent: US4325956 A1, 1982 ;
反应条件
[TMG][Lac]
T=95°C; 0.5 h; Ionic liquid;
参考文献
Chavan, Sunil S.; Shelke, Rupesh U.; Degani, Mariam S.
Monatshefte fur Chemie, 2013 , vol. 144, # 3 p. 399 - 403
反应条件
1: acetic acid anhydride
2: aq. NaOH solution
View Scheme
参考文献
Papesch; Schroeder
Journal of Organic Chemistry, 1951 , vol. 16, p. 1879,1881,1887
反应条件
1.1: HMDS; (NH4)2SO4 / Heating
1.2: Heating
2.1: aq. NaNO2; HOAc
2.2: Na2S2O4; NH4OH / 85 - 95 °C
3.1: Heating
View Scheme
参考文献
Foley, Louise H.; Wang, Ping; Dunten, Pete; Ramsey, Gwendolyn; Gubler, Mary-Lou; Wertheimer, Stanley J.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3607 - 3610
反应条件
sodium hydroxide; ethanol
参考文献
Papesch; Schroeder
Journal of Organic Chemistry, 1951 , vol. 16, p. 1879,1881,1887
反应条件
1.1: HMDS; (NH4)2SO4 / Heating
1.2: Heating
2.1: aq. NaNO2; HOAc
2.2: Na2S2O4; NH4OH / 85 - 95 °C
3.1: EDCI; imidazole
3.2: DMAP / dimethylformamide
4.1: aq. NaOH / methanol / 50 °C
View Scheme
参考文献
Foley, Louise H.; Wang, Ping; Dunten, Pete; Ramsey, Gwendolyn; Gubler, Mary-Lou; Wertheimer, Stanley J.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3607 - 3610
反应条件
1.1: HMDS; (NH4)2SO4 / Heating
1.2: Heating
2.1: aq. NaNO2; HOAc
2.2: Na2S2O4; NH4OH / 85 - 95 °C
3.1: EDCI; imidazole
3.2: DMAP / dimethylformamide
View Scheme
参考文献
Foley, Louise H.; Wang, Ping; Dunten, Pete; Ramsey, Gwendolyn; Gubler, Mary-Lou; Wertheimer, Stanley J.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3607 - 3610
反应条件
1.1: HMDS; (NH4)2SO4 / Heating
1.2: Heating
2.1: aq. NaNO2; HOAc
2.2: Na2S2O4; NH4OH / 85 - 95 °C
3.1: EDCI; imidazole
3.2: DMAP / dimethylformamide
View Scheme
参考文献
Foley, Louise H.; Wang, Ping; Dunten, Pete; Ramsey, Gwendolyn; Gubler, Mary-Lou; Wertheimer, Stanley J.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3607 - 3610
