6-氨基-1-苄基-3-甲基-1H-嘧啶-2,4-二酮合成路线 （共 3 条）
反应条件
sodium hydroxide in water
T=5 - 10°C; 1 h;
参考文献
Agostini; Bonacchi; Coppini; Di Marco; Paoli; Toja
Arzneimittel-Forschung/Drug Research, 1995 , vol. 45, # 6 p. 684 - 688
反应条件
sodium hydroxide; acetic anhydride
1.) 70 deg C, 2 h, 2.) from 20 to 70 deg C, 1 h; Multistep reaction;
参考文献
Merlos; Gomez; Vericat; Bartroli; Garcia-Rafanell; Forn
European Journal of Medicinal Chemistry, 1990 , vol. 25, # 8 p. 653 - 658
反应条件
1: NaNO2, AcOH / H2O / 2 h / Ambient temperature
2: Na2S2O4, 25percent aq. NH4OH / 20 - 50 °C
3: 2.) 2.2 M aq. NaOH / 1.) reflux, 2 h, 2.) reflux, 45 min
View Scheme
参考文献
Merlos; Gomez; Vericat; Bartroli; Garcia-Rafanell; Forn
European Journal of Medicinal Chemistry, 1990 , vol. 25, # 8 p. 653 - 658
