1: 3-Iodo-4-methoxy-2(1H)-quinolinone With isopropylmagnesium chloride in tetrahydrofuran T=-30°C; 0.166667 h; 2: (+/-)-3,3-dimethyloxirane-2-carboxaldehyde in tetrahydrofuran T=-30°C; 0.5 h; Further stages.;

1: With potassium hydroxide; calcium chloride in methanol T=25°C; 24 h; 2: With N,N-dimethyl-formamide dimethyl acetal in diethyl ether 6 h; Heating;

1: 1.) 80percent NaH / 1.) dioxane, 30 min, room temp.; 2.) 3h, room temp. 2: 93 percent / H2 / tris(triphenylphosphane)rhodium(I)chloride / benzene / 8 h / Ambient temperature View Scheme

1: With potassium hydroxide; calcium chloride in methanol T=25°C; 24 h; 2: With trifluoroacetic acid in dichloromethane T=25°C; 2 h;