2-溴-4-(羧基甲基)苯基苯甲酸酯合成路线 （共 4 条）
反应条件
sodium tetrahydroborate in tetrahydrofuran
T=20°C;
参考文献
Woo, L.W. Lawrence; Suteliffe, Oliver B.; Bubert, Christian; Grasso, Anna; Chander, Surinder K.; Purohit, Atul; Reed, Michael J.; Potter, Barry V. L.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 15 p. 3193 - 3196
反应条件
1: 89 percent / Et3N / ethyl acetate / 5 h / 20 °C
2: 96 percent / NaBH4 / ethanol / 0 - 20 °C
View Scheme
参考文献
Woo, L. W. Lawrence; Bubert, Christian; Sutcliffe, Oliver-B.; Smith, Andrew; Chander, Surinder K.; Mahon, Mary F.; Purohit, Atul; Reed, Michael J.; Potter, Barry V. L.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 15 p. 3540 - 3560
反应条件
1: Br2; AcOH
2: 89 percent / Et3N / ethyl acetate / 5 h / 20 °C
3: 96 percent / NaBH4 / ethanol / 0 - 20 °C
View Scheme
参考文献
Woo, L. W. Lawrence; Bubert, Christian; Sutcliffe, Oliver-B.; Smith, Andrew; Chander, Surinder K.; Mahon, Mary F.; Purohit, Atul; Reed, Michael J.; Potter, Barry V. L.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 15 p. 3540 - 3560
反应条件
phosphorus tribromide in dichloromethane
T=0 - 20°C;
参考文献
Potter, Barry Victor Lloyd; Woo, Lok Wai Lawrence; Purohit, Atul; Reed, Michael John; Sutcliffe, Oliver Brook; Bubert, Christian
Patent: US2004/19016 A1, 2004 ;
Location in patent: Page/Page column 49 ;
