2-溴-4-溴甲基苯甲酸苯酯合成路线 （共 7 条）
反应条件
phosphorus tribromide in dichloromethane
T=0 - 20°C;
参考文献
Potter, Barry Victor Lloyd; Woo, Lok Wai Lawrence; Purohit, Atul; Reed, Michael John; Sutcliffe, Oliver Brook; Bubert, Christian
Patent: US2004/19016 A1, 2004 ;
Location in patent: Page/Page column 49 ;
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane
2 h; Heating;
参考文献
Woo, L. W. Lawrence; Bubert, Christian; Sutcliffe, Oliver-B.; Smith, Andrew; Chander, Surinder K.; Mahon, Mary F.; Purohit, Atul; Reed, Michael J.; Potter, Barry V. L.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 15 p. 3540 - 3560
反应条件
1: 89 percent / Et3N / ethyl acetate / 5 h / 20 °C
2: 96 percent / NaBH4 / ethanol / 0 - 20 °C
3: 87 percent / PBr3 / CH2Cl2 / 3 h / 0 - 20 °C
View Scheme
参考文献
Woo, L. W. Lawrence; Bubert, Christian; Sutcliffe, Oliver-B.; Smith, Andrew; Chander, Surinder K.; Mahon, Mary F.; Purohit, Atul; Reed, Michael J.; Potter, Barry V. L.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 15 p. 3540 - 3560
反应条件
1: 96 percent / NaBH4 / ethanol / 0 - 20 °C
2: 87 percent / PBr3 / CH2Cl2 / 3 h / 0 - 20 °C
View Scheme
参考文献
Woo, L. W. Lawrence; Bubert, Christian; Sutcliffe, Oliver-B.; Smith, Andrew; Chander, Surinder K.; Mahon, Mary F.; Purohit, Atul; Reed, Michael J.; Potter, Barry V. L.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 15 p. 3540 - 3560
反应条件
1: 64 percent / Et3N / ethyl acetate
2: 62 percent / N-bromosuccinimide; benzoyl peroxide / CCl4 / 2 h / Heating
View Scheme
参考文献
Woo, L. W. Lawrence; Bubert, Christian; Sutcliffe, Oliver-B.; Smith, Andrew; Chander, Surinder K.; Mahon, Mary F.; Purohit, Atul; Reed, Michael J.; Potter, Barry V. L.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 15 p. 3540 - 3560
反应条件
1: Br2; AcOH
2: 89 percent / Et3N / ethyl acetate / 5 h / 20 °C
3: 96 percent / NaBH4 / ethanol / 0 - 20 °C
4: 87 percent / PBr3 / CH2Cl2 / 3 h / 0 - 20 °C
View Scheme
参考文献
Woo, L. W. Lawrence; Bubert, Christian; Sutcliffe, Oliver-B.; Smith, Andrew; Chander, Surinder K.; Mahon, Mary F.; Purohit, Atul; Reed, Michael J.; Potter, Barry V. L.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 15 p. 3540 - 3560
反应条件
1: 64 percent / Et3N / ethyl acetate
2: 62 percent / N-bromosuccinimide; benzoyl peroxide / CCl4 / 2 h / Heating
View Scheme
参考文献
Woo, L. W. Lawrence; Bubert, Christian; Sutcliffe, Oliver-B.; Smith, Andrew; Chander, Surinder K.; Mahon, Mary F.; Purohit, Atul; Reed, Michael J.; Potter, Barry V. L.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 15 p. 3540 - 3560
