(4-(苄氧基)-3-氟苯基)甲醇合成路线 （共 3 条）
反应条件
1: With sodium tetrahydroborate in tetrahydrofuran
T=20°C;
2: With water in tetrahydrofuran
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; AJINOMOTO CO., INC.; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2007/14895 A2, 2007 ;
Location in patent: Page/Page column 33 ;
反应条件
1: 95 percent / K2CO3 / dimethylformamide / 18 h / 20 °C
2: 97 percent / NaBH4 / ethanol; tetrahydrofuran / 0 - 20 °C
View Scheme
参考文献
Woo, L. W. Lawrence; Bubert, Christian; Sutcliffe, Oliver-B.; Smith, Andrew; Chander, Surinder K.; Mahon, Mary F.; Purohit, Atul; Reed, Michael J.; Potter, Barry V. L.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 15 p. 3540 - 3560
反应条件
1: 95 percent / K2CO3 / dimethylformamide / 18 h / 20 °C
2: 97 percent / NaBH4 / ethanol; tetrahydrofuran / 0 - 20 °C
View Scheme
参考文献
Woo, L. W. Lawrence; Bubert, Christian; Sutcliffe, Oliver-B.; Smith, Andrew; Chander, Surinder K.; Mahon, Mary F.; Purohit, Atul; Reed, Michael J.; Potter, Barry V. L.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 15 p. 3540 - 3560
