2-甲氧基-5-苯基吡啶合成路线 （共 14 条）
反应条件
potassium phosphate; tris(dibenzylideneacetone)dipalladium (0); tri-cyclo-hexyl-phosphine in 1,4-dioxane; water
T=100°C; 18 h;
参考文献
Kudo, Noriaki; Perseghini, Mauro; Fu, Gregory C.
Angewandte Chemie - International Edition, 2006 , vol. 45, # 8 p. 1282 - 1284
反应条件
Ph2P(CH2CH2O)22CH3; triethylamine; palladium dichloride in water
T=100°C; Suzuki coupling; 1 h; Inert atmosphere;
参考文献
Liu, Ning; Liu, Chun; Yan, Bo; Jin, Zilin
Applied Organometallic Chemistry, 2011 , vol. 25, # 3 p. 168 - 172
反应条件
caesium carbonate in water
T=100°C; Suzuki coupling; 0.166667 h; Microwave irradiation;
参考文献
Worm-Leonhard, Kasper; Meldal, Morten
European Journal of Organic Chemistry, 2008 , # 31 p. 5244 - 5253
反应条件
caesium carbonate in water
T=90°C; Suzuki coupling; 0.166667 h; Microwave irradiation;
参考文献
Worm-Leonhard, Kasper; Meldal, Morten
European Journal of Organic Chemistry, 2008 , # 31 p. 5244 - 5253
反应条件
P(NC5H10)3; nickel dichloride in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
T=100°C; Negishi cross-coupling reaction;
参考文献
Gerber, Roman; Frech, Christian M.
Chemistry - A European Journal, 2011 , vol. 17, # 42 p. 11893 - 11904
反应条件
1: phenyl-trifluoro-silane With tetrabutyl ammonium fluoride; palladium diacetate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in tert-butyl alcohol
T=20°C; Hiyama cross-coupling reaction; 0.0833333 h; Inert atmosphereSealed vial;
2: 5-chloro-2-methoxypyridine in tert-butyl alcohol
T=60°C; Hiyama cross-coupling reaction; Inert atmosphereSealed vial;
参考文献
Molander, Gary A.; Iannazzo, Laura
Journal of Organic Chemistry, 2011 , vol. 76, # 21 p. 9182 - 9187
反应条件
4,5-dimethyl-3-(2-phenoxyphenyl)-1-(2,4,6-trimethylbenzyl)imidazolium chloride; palladium diacetate; caesium carbonate in 1,4-dioxane
T=90°C; Suzuki-Miyaura Coupling; 18 h; Inert atmosphere;
参考文献
Kuriyama, Masami; Matsuo, Seira; Shinozawa, Mina; Onomura, Osamu
Organic Letters, 2013 , vol. 15, # 11 p. 2716 - 2719
反应条件
1: 6-Methoxy-pyridin-3-ylamine; 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl-4',4',5',5'-tetramethyl-1,3,2-dioxaborolane With tert.-butylnitrite in acetonitrile
T=80°C; 2 h;
2: iodobenzene With tetrakis(triphenylphosphine) palladium(0); potassium carbonate in N,N-dimethyl-formamide
T=100°C; Suzuki-Miyaura Coupling; 12 h; Inert atmosphere;
参考文献
Qiu, Di; Jin, Liang; Zheng, Zhitong; Meng, He; Mo, Fanyang; Wang, Xi; Zhang, Yan; Wang, Jianbo
Journal of Organic Chemistry, 2013 , vol. 78, # 5 p. 1923 - 1933
反应条件
1.1: sodium hexafluorosilicate / 1 h / 200 °C / Inert atmosphere
2.1: tetrabutyl ammonium fluoride; palladium diacetate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl / tert-butyl alcohol / 0.08 h / 20 °C / Inert atmosphere; Sealed vial
2.2: 60 °C / Inert atmosphere; Sealed vial
View Scheme
参考文献
Molander, Gary A.; Iannazzo, Laura
Journal of Organic Chemistry, 2011 , vol. 76, # 21 p. 9182 - 9187
反应条件
1: sodium methylate / methanol / 0.5 h / |Reflux
2: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / anhydrous xylene / 5 h / |Reflux
View Scheme
参考文献
Hibi, Shigeki; Ueno, Koshi; Nagato, Satoshi; Kawano, Koki; Ito, Koichi; Norimine, Yoshihiko; Takenaka, Osamu; Hanada, Takahisa; Yonaga, Masahiro
Journal of Medicinal Chemistry, 2012 , vol. 55, # 23 p. 10584 - 10600
