1-(4-甲基苄基)-1H-苯并咪唑-2-甲醛合成路线 （共 3 条）
反应条件
1: 1-(4-methylbenzyl)-1H-benzo[d]imidazole With n-butyllithium in tetrahydrofuran
T=-75°C; 1 h; Inert atmosphere;
2: N,N-dimethyl-formamide in tetrahydrofuran
T=75°C; 1 h; Inert atmosphere;
参考文献
Zhu, Wufu; Zhai, Xin; Fu, Qiangqiang; Guo, Fei; Bai, Mei; Wang, Jianqiang; Wang, Haiyan; Gong, Ping
Chemical and Pharmaceutical Bulletin, 2012 , vol. 60, # 8 p. 1037 - 1045
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 50 °C
2.1: n-butyllithium / tetrahydrofuran / 1 h / -75 °C / Inert atmosphere
2.2: 1 h / 75 °C / Inert atmosphere
View Scheme
参考文献
Zhu, Wufu; Zhai, Xin; Fu, Qiangqiang; Guo, Fei; Bai, Mei; Wang, Jianqiang; Wang, Haiyan; Gong, Ping
Chemical and Pharmaceutical Bulletin, 2012 , vol. 60, # 8 p. 1037 - 1045
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 50 °C
2.1: n-butyllithium / tetrahydrofuran / 1 h / -75 °C / Inert atmosphere
2.2: 1 h / 75 °C / Inert atmosphere
View Scheme
参考文献
Zhu, Wufu; Zhai, Xin; Fu, Qiangqiang; Guo, Fei; Bai, Mei; Wang, Jianqiang; Wang, Haiyan; Gong, Ping
Chemical and Pharmaceutical Bulletin, 2012 , vol. 60, # 8 p. 1037 - 1045
