1: 1-bromo-3,5-difluoro-benzene With n-butyllithium; diisopropylamine in tetrahydrofuran; n-heptane T=-80 - -75°C; 2.08333 h; 2: N,N-dimethyl-formamide in tetrahydrofuran; n-heptane T=-80°C; 0.25 h; 3: With acetic acid in tetrahydrofuran; diethyl ether; n-heptane T=20 - 80°C; pH=~ 4 - 5; 0.25 h;

pyridine-SO3 complex; dimethyl sulfoxide; triethylamine in dichloromethane T=20°C; 3 h;

1: 1-bromo-3,5-difluoro-benzene With lithium diisopropyl amide in tetrahydrofuran T=-70°C; 0.5 h; 2: 1-piperidinecarboxaldehyde T=-70 - 0°C;

1: methanol / 3.5 h / 0 °C / |Reflux 2: hydrazine hydrate / ethylene glycol / 24 h / 95 °C View Scheme

Oxonereg; in N,N-dimethyl-formamide T=20°C; 12 h;