2-氨基对苯二甲酸二甲酯合成路线 （共 39 条）
反应条件
1.1: tetrachloromethane; N-chloro-succinimide / 16 h / 80 °C 2.1: isopentyl nitrite / tetrahydrofuran / 3 h / 20 °C / |Reflux 3.1: water; sodium hydroxide / tetrahydrofuran / 48 h / 20 °C 4.1: triethylamine / tetrahydrofuran / 0.33 h / 20 °C 4.2: 18 h / 20 °C 5.1: pyridine; trifluoroacetic anhydride / 1,4-dioxane / 24 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 56, # 11 p. 4521 - 4536
反应条件
1.1: N-chloro-succinimide / isopropyl alcohol / 24 h / 85 °C 2.1: potassium hydroxide / tetrahydrofuran; water / 48 h / Reflux 2.2: 0 °C View Scheme
参考文献
Kim, Min; Boissonnault, Jake A.; Dau, Phuong V.; Cohen, Seth M.
Angewandte Chemie - International Edition, 2011 , vol. 50, # 51 p. 12193 - 12196
反应条件
in DMF (N,N-dimethyl-formamide) T=135°C; 2 h;
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US6348474 B1, 2002 ;
Location in patent: Page column 83 ;
反应条件
1: sulfuric acid; sodium nitrite / water / 1 h / 0 - 5 °C 2: potassium iodide / water / 0.33 h / 60 °C View Scheme
参考文献
Ivan, Nathaniel; Benin, Vladimir; Morgan, Alexander B.
Synthetic Communications, 2013 , vol. 43, # 13 p. 1831 - 1836
参考文献
Weinges, Klaus; Reinel, Ute; Maurer, Wolfgang; Gaessler, Norbert
Liebigs Annalen der Chemie, 1987 , p. 833 - 838
反应条件
sulfuric acid; sodium nitrite in water T=0 - 5°C; 1 h;
参考文献
Ivan, Nathaniel; Benin, Vladimir; Morgan, Alexander B.
Synthetic Communications, 2013 , vol. 43, # 13 p. 1831 - 1836
反应条件
1: 1 N NaOH / 2 h / Heating 2: benzene; H2O / 4 h View Scheme
参考文献
Sircar, Jagadish C.; Capiris, Thomas; Kesten, Stephen J.; Herzig, David J.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 6 p. 735 - 742
反应条件
1: With sulfuric acid; sodium nitrite T=0°C; 0.5 h; 2: With sulfuric acid T=120°C; Sandmeyer reaction; 0.333333 h; Further stages.;
参考文献
Journal of Materials Chemistry, , vol. 17, # 19 p. 1981 - 1988
反应条件
1: in 1,2-dichloro-ethane 3 h; Heating / reflux; 2: With triethylamine in 1,2-dichloro-ethane 24 h; Heating / reflux;
参考文献
CORTEX PHARMACEUTICALS, INC.
Patent: WO2008/85505 A1, 2008 ;
Location in patent: Page/Page column 105-106 ;
反应条件
sulfuryl dichloride in dichloromethane T=0°C; 1 h; Heating / reflux;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2004/80970 A1, 2004 ;
Location in patent: Page 63 ;
WO 2004/080970 A1
