反应条件
1.1: tetrachloromethane; N-chloro-succinimide / 16 h / 80 °C
2.1: isopentyl nitrite / tetrahydrofuran / 3 h / 20 °C / |Reflux
3.1: water; sodium hydroxide / tetrahydrofuran / 48 h / 20 °C
4.1: triethylamine / tetrahydrofuran / 0.33 h / 20 °C
4.2: 18 h / 20 °C
5.1: pyridine; trifluoroacetic anhydride / 1,4-dioxane / 24 h / 20 °C
6.1: pyridine; lithium iodide / 2 h / 20 °C / |Reflux
View Scheme
参考文献
Liang, Jun; Van Abbema, Anne; Balazs, Mercedesz; Barrett, Kathy; Berezhkovsky, Leo; Blair, Wade; Chang, Christine; Delarosa, Donnie; Devoss, Jason; Driscoll, Jim; Eigenbrot, Charles; Ghilardi, Nico; Gibbons, Paul; Halladay, Jason; Johnson, Adam; Kohli, Pawan Bir; Lai, Yingjie; Liu, Yanzhou; Lyssikatos, Joseph; Mantik, Priscilla; Menghrajani, Kapil; Murray, Jeremy; Peng, Ivan; Sambrone, Amy; Shia, Steven; Shin, Young; Smith, Jan; Sohn, Sue; Tsui, Vickie; Ultsch, Mark; Wu, Lawren C.; Xiao, Yisong; Yang, Wenqian; Young, Judy; Zhang, Birong; Zhu, Bing-Yan; Magnuson, Steven
Journal of Medicinal Chemistry, 2013 , vol. 56, # 11 p. 4521 - 4536