1.1: aluminium hydride / diethyl ether / -30 °C 1.2: -30 °C 2.1: pyridine / 5 h / 0 - 20 °C 3.1: Pseudomonas sp. lipase; water / 0.08 h / 20 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction 4.1: sodium hydroxide / water / 30 °C / pH 7.1 / Microbiological reaction; Yeast peptone dextrose broth; Enzymatic reaction 5.1: methanol; potassium carbonate / 1 h / 20 °C View Scheme

1.1: aluminium hydride / diethyl ether / -30 °C 1.2: -30 °C 2.1: pyridine / 5 h / 0 - 20 °C 3.1: Pseudomonas sp. lipase; water / 0.08 h / 20 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction 4.1: sodium hydroxide / water / 30 °C / pH 7.1 / Microbiological reaction; Yeast peptone dextrose broth; Enzymatic reaction 5.1: methanol; potassium carbonate / 1 h / 20 °C View Scheme

sulfuric acid in benzene T=70°C; 48 h;

sulfuric acid in cyclohexane Heating;

optically active salen ligand Co(II) complex C23H26N2O4Co in N,N-dimethyl-formamide; toluene Product distribution;

1: With aluminium hydride in diethyl ether T=-30°C; 2: With sulfuric acid in diethyl ether; water T=-30°C;