(S)-(+)-1,2,3,4-四氢-1-萘酚合成路线 （共 60 条）
反应条件
1: 1-hydroxy-1,2,3,4-tetrahydronaphthalene With (-)-Tetramisole; N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=-78°C; Inert atmosphereMolecular sieveResolution of racemate; 2: (4-tBuC6H4)3SiCl in tetrahydrofuran T=-78°C; 69 h; Inert atmosphereMolecular sieveResolution of racemate; enantioselective reaction;
参考文献
Akhani, Ravish K.; Moore, Maggie I.; Pribyl, Julia G.; Wiskur, Sheryl L.
Journal of Organic Chemistry, 2014 , vol. 79, # 6 p. 2384 - 2396
反应条件
1: 1-hydroxy-1,2,3,4-tetrahydronaphthalene With (-)-Tetramisole; N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=-78°C; Inert atmosphereMolecular sieveResolution of racemate; 2: (tris-(4-fluorophenyl))chlorosilane in tetrahydrofuran T=-78°C; 24 h; Inert atmosphereMolecular sieveResolution of racemate; enantioselective reaction;
参考文献
Akhani, Ravish K.; Moore, Maggie I.; Pribyl, Julia G.; Wiskur, Sheryl L.
Journal of Organic Chemistry, 2014 , vol. 79, # 6 p. 2384 - 2396
反应条件
1: 1-hydroxy-1,2,3,4-tetrahydronaphthalene With (-)-Tetramisole; N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=-78°C; Inert atmosphereMolecular sieveResolution of racemate; 2: tris(4-bromophenyl)chlorosilane in tetrahydrofuran T=-78°C; 24 h; Inert atmosphereMolecular sieveResolution of racemate; enantioselective reaction;
参考文献
Akhani, Ravish K.; Moore, Maggie I.; Pribyl, Julia G.; Wiskur, Sheryl L.
Journal of Organic Chemistry, 2014 , vol. 79, # 6 p. 2384 - 2396
反应条件
1: cis-4-hydroxy-3,4-dihydro-1-benzopyran With (-)-Tetramisole; N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=-78°C; Inert atmosphereMolecular sieveResolution of racemate; 2: tris(4-bromophenyl)chlorosilane in tetrahydrofuran T=-78°C; 24 h; Inert atmosphereMolecular sieveResolution of racemate; enantioselective reaction;
参考文献
Akhani, Ravish K.; Moore, Maggie I.; Pribyl, Julia G.; Wiskur, Sheryl L.
Journal of Organic Chemistry, 2014 , vol. 79, # 6 p. 2384 - 2396
反应条件
1: cis-4-hydroxy-3,4-dihydro-1-benzopyran With (-)-Tetramisole; N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=-78°C; Inert atmosphereMolecular sieveResolution of racemate; 2: chlorotris(4-chlorophenyl)silane in tetrahydrofuran T=-78°C; 24 h; Inert atmosphereMolecular sieveResolution of racemate; enantioselective reaction;
参考文献
Akhani, Ravish K.; Moore, Maggie I.; Pribyl, Julia G.; Wiskur, Sheryl L.
Journal of Organic Chemistry, 2014 , vol. 79, # 6 p. 2384 - 2396
反应条件
1: cis-4-hydroxy-3,4-dihydro-1-benzopyran With (-)-Tetramisole; N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=-78°C; Inert atmosphereMolecular sieveResolution of racemate; 2: (tris-(4-fluorophenyl))chlorosilane in tetrahydrofuran T=-78°C; 24 h; Inert atmosphereMolecular sieveResolution of racemate; enantioselective reaction;
参考文献
Akhani, Ravish K.; Moore, Maggie I.; Pribyl, Julia G.; Wiskur, Sheryl L.
Journal of Organic Chemistry, 2014 , vol. 79, # 6 p. 2384 - 2396
反应条件
1: cis-4-hydroxy-3,4-dihydro-1-benzopyran With (-)-Tetramisole; N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=-78°C; Inert atmosphereMolecular sieveResolution of racemate; 2: triphenyl-silyl chloride in tetrahydrofuran T=-78°C; 24 h; Inert atmosphereMolecular sieveResolution of racemate; enantioselective reaction;
参考文献
Akhani, Ravish K.; Moore, Maggie I.; Pribyl, Julia G.; Wiskur, Sheryl L.
Journal of Organic Chemistry, 2014 , vol. 79, # 6 p. 2384 - 2396
反应条件
1: cis-4-hydroxy-3,4-dihydro-1-benzopyran With (-)-Tetramisole; N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=-78°C; Inert atmosphereMolecular sieveResolution of racemate; 2: chlorotris(p-methylphenyl)silane in tetrahydrofuran T=-78°C; 48 h; Inert atmosphereMolecular sieveResolution of racemate; enantioselective reaction;
参考文献
Akhani, Ravish K.; Moore, Maggie I.; Pribyl, Julia G.; Wiskur, Sheryl L.
Journal of Organic Chemistry, 2014 , vol. 79, # 6 p. 2384 - 2396
反应条件
1: 1-hydroxy-1,2,3,4-tetrahydronaphthalene With (-)-Tetramisole; N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=-78°C; Inert atmosphereMolecular sieveResolution of racemate; 2: chlorotris(4-chlorophenyl)silane in tetrahydrofuran T=-78°C; 24 h; Inert atmosphereMolecular sieveResolution of racemate; enantioselective reaction;
参考文献
Akhani, Ravish K.; Moore, Maggie I.; Pribyl, Julia G.; Wiskur, Sheryl L.
Journal of Organic Chemistry, 2014 , vol. 79, # 6 p. 2384 - 2396
参考文献
Noe, Christian R.; Knollmueller, Max; Wagner, Ernst; Voellenkle, Horst
Chemische Berichte, 1985 , vol. 118, # 5 p. 1733 - 1745
