4-氯-吡啶-2-酰氯合成路线

参考文献

F. HOFFMANN-LA ROCHE LTD; EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL); SAVIRA PHARMACEUTICALS GMBH; CLASSEN-HOUBEN, Dirk; WOLKERSTORFER, Andrea; SZOLAR, Oliver; SMITH, Mark; SO, Sung-Sau; CUSACK, Stephen; LANGER, Thierry; GIETHLEN, Bruno; MORICE, Christophe; MICHAUT-SIMON, Céline; JUNG, Laurence
Patent: US2013/102601 A1, 2013 ;

53750-66-64-氯-吡啶-2-酰氯

284462-37-94-(4-氨基苯氧基)-N-甲基-2-吡啶甲酰胺

参考文献

Molecules, , vol. 16, # 6 p. 5130 - 5141

53750-66-64-氯-吡啶-2-酰氯+

124-40-3二甲胺

114780-06-24-氯-N,N-二甲基吡啶酰胺

参考文献

Amiri, Payman; Fantl, Wendy; Levine, Barry Haskell; Poon, Daniel J.; Ramurthy, Savithri; Renhowe, Paul A.; Subramanian, Sharadha; Sung, Leonard
Patent: US2004/122237 A1, 2004 ;
Location in patent: Page 248 ;
US 20040122237 A1

53750-66-64-氯-吡啶-2-酰氯+

74497-02-2

133928-61-74-氯-n-苯基吡啶甲酰胺

参考文献

Nora De Souza, Marcus V.; Dodd, Robert H.
Heterocycles, 1998 , vol. 47, # 2 p. 811 - 827

53750-66-64-氯-吡啶-2-酰氯

1130115-44-4索拉非尼-d3

参考文献

US2013/12548 A1, ;

53750-66-64-氯-吡啶-2-酰氯

1020172-07-9Rebastinib

参考文献

DECIPHERA PHARMACEUTICALS, LLC; FLYNN, Daniel L.; PETILLO, Peter A.; KAUFMAN, Michael D.
Patent: WO2013/36232 A2, 2013 ;

53750-66-64-氯-吡啶-2-酰氯+

108-18-9二异丙胺

168428-76-04-氯-N,N-二异丙基吡啶酰胺

参考文献

Sammakia, Tarek; Stangeland, Eric L; Whitcomb, Mark C
Organic letters, 2002 , vol. 4, # 14 p. 2385 - 2388

53750-66-64-氯-吡啶-2-酰氯

10201-73-72-氨基-4-甲氧基吡啶

参考文献

EP2314588 A1, ;

53750-66-64-氯-吡啶-2-酰氯

19798-80-22-氨基-4-氯吡啶

参考文献

Wang, Jun; Zhan, Peng; Li, Zhenyu; Liu, Huiqing; De Clercq, Erik; Pannecouque, Christophe; Liu, Xinyong
European Journal of Medicinal Chemistry, 2014 , vol. 76, p. 531 - 538

53750-66-64-氯-吡啶-2-酰氯

187973-18-84-甲氧基吡啶-2-羧酸肼

参考文献

Guangzhou Institute Of Biomedicine And Health, Chinese Academy Of Sciences
Patent: EP2314588 A1, 2011 ;