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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
53755-58-1
合成路线
（共 10 条）
72704-01-9
甲基(E)-3-[4-羟基-3-(3-甲基丁-2-烯基)苯基]丙-2-烯酸酯
→
反应条件
53755-58-1
反应条件
sodium hydroxide in water 2.5 h; Heating;
参考文献
Menon, Sanjay R.; Patel, Vishal K.; Mitscher, Lester A.; Shih, Peter; Pillai, Segaran P.; Shankel, Delbert M.
Journal of Natural Products, 1999 , vol. 62, # 1 p. 102 - 106
1208233-14-0
→
反应条件
53755-58-1
反应条件
1: With 2,6-dimethylpyridine; trimethylsilyl trifluoromethanesulfonate in dichloromethane T=20°C; Inert atmosphere; 2: With hydrogenchloride; water in tetrahydrofuran T=20°C; Inert atmosphere;
参考文献
Tani, Hiroko; Hasumi, Keiko; Tatefuji, Tomoki; Hashimoto, Ken; Koshino, Hiroyuki; Takahashi, Shunya
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 1 p. 151 - 157
151071-02-2
→
反应条件
53755-58-1
反应条件
sodium hydroxide in methanol 1 h; Heating;
参考文献
Bates, Roderick W.; Gabel, Christine J.; Ji, Jianhua; Rama-Devi, Thota
Tetrahedron, 1995 , vol. 51, # 30 p. 8199 - 8212
540-38-5
4-碘苯酚
→
反应条件
53755-58-1
反应条件
1: 58 percent / NaH / toluene / 1 h / 20 °C 2: 96 percent / 4-(dimethylamino)pyridine / CH2Cl2 / 4 h / Heating 3: 93 percent / Et3N; tri(o-tolyl)phosphine / Pd(OAc)2 / toluene / 20 h / Heating 4: 74 percent / KOH / H2O; methanol / 3 h / Heating View Scheme
参考文献
Uto, Yoshihiro; Ae, Shutaro; Koyama, Daisuke; Sakakibara, Mitsutoshi; Otomo, Naoki; Otsuki, Mamoru; Nagasawa, Hideko; Kirk, Kenneth L.; Hori, Hitoshi
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 16 p. 5721 - 5728
151071-03-3
4-碘-2-(3-甲基-2-丁烯基)-苯酚
→
反应条件
53755-58-1
反应条件
1: 96 percent / 4-(dimethylamino)pyridine / CH2Cl2 / 4 h / Heating 2: 93 percent / Et3N; tri(o-tolyl)phosphine / Pd(OAc)2 / toluene / 20 h / Heating 3: 74 percent / KOH / H2O; methanol / 3 h / Heating View Scheme
参考文献
Uto, Yoshihiro; Ae, Shutaro; Koyama, Daisuke; Sakakibara, Mitsutoshi; Otomo, Naoki; Otsuki, Mamoru; Nagasawa, Hideko; Kirk, Kenneth L.; Hori, Hitoshi
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 16 p. 5721 - 5728
151071-04-4
→
反应条件
53755-58-1
反应条件
1: 93 percent / Et3N; tri(o-tolyl)phosphine / Pd(OAc)2 / toluene / 20 h / Heating 2: 74 percent / KOH / H2O; methanol / 3 h / Heating View Scheme
参考文献
Uto, Yoshihiro; Ae, Shutaro; Koyama, Daisuke; Sakakibara, Mitsutoshi; Otomo, Naoki; Otsuki, Mamoru; Nagasawa, Hideko; Kirk, Kenneth L.; Hori, Hitoshi
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 16 p. 5721 - 5728
870-63-3
1-溴-3-甲基-2-丁烯
→
反应条件
53755-58-1
反应条件
1: 58 percent / NaH / toluene / 1 h / 20 °C 2: 96 percent / 4-(dimethylamino)pyridine / CH2Cl2 / 4 h / Heating 3: 93 percent / Et3N; tri(o-tolyl)phosphine / Pd(OAc)2 / toluene / 20 h / Heating 4: 74 percent / KOH / H2O; methanol / 3 h / Heating View Scheme
参考文献
Uto, Yoshihiro; Ae, Shutaro; Koyama, Daisuke; Sakakibara, Mitsutoshi; Otomo, Naoki; Otsuki, Mamoru; Nagasawa, Hideko; Kirk, Kenneth L.; Hori, Hitoshi
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 16 p. 5721 - 5728
7400-08-0
对羟基肉桂酸
→
反应条件
53755-58-1
反应条件
1: 63 percent / H2SO4 / Heating 2: 1.) NaH / 1.) toluene, 60 - 65 deg C, 3.5 h, 2.) 35 deg C, 72 h. 3: 87 percent / NaOH / H2O / 2.5 h / Heating View Scheme
参考文献
Menon, Sanjay R.; Patel, Vishal K.; Mitscher, Lester A.; Shih, Peter; Pillai, Segaran P.; Shankel, Delbert M.
Journal of Natural Products, 1999 , vol. 62, # 1 p. 102 - 106
3943-97-3
4-羟基肉桂酸甲酯
→
反应条件
53755-58-1
反应条件
1: 1.) NaH / 1.) toluene, 60 - 65 deg C, 3.5 h, 2.) 35 deg C, 72 h. 2: 87 percent / NaOH / H2O / 2.5 h / Heating View Scheme
参考文献
Menon, Sanjay R.; Patel, Vishal K.; Mitscher, Lester A.; Shih, Peter; Pillai, Segaran P.; Shankel, Delbert M.
Journal of Natural Products, 1999 , vol. 62, # 1 p. 102 - 106
186581-53-3
重氮甲烷
+
53755-58-1
→
反应条件
72704-01-9
甲基(E)-3-[4-羟基-3-(3-甲基丁-2-烯基)苯基]丙-2-烯酸酯
反应条件
in diethyl ether T=0°C; 2 h;
参考文献
Bisogno, Fabricio; Mascoti, Laura; Sanchez, Cecilia; Garibotto, Francisco; Giannini, Fernando; Kurina-Sanz, Marcela; Enriz, Ricardo
Journal of Agricultural and Food Chemistry, 2007 , vol. 55, # 26 p. 10635 - 10640
