(3S,4r)-3-甲基-4-n-苯氨基哌啶合成路线 (共 4 条)
反应条件
1: 10 g / H2 / 10percent Pd/C / ethanol / 6 h / 60 °C / 775.7 Torr
View Scheme
参考文献
Wang; Zhu; Jin; Chen; Ji; Chi
Journal of Medicinal Chemistry, 1995 , vol. 38, # 18 p. 3652 - 3659
反应条件
1: 2.) NaBH4 / 1.) toluene, EtOH, 2.) toluene, EtOH
2: HCl, H2 / Pd(OH)2/C / methanol / 120 h / 2068.6 Torr
View Scheme
参考文献
Brine, George A.; Stark, Peter A.; Liu, Young; Carrol, F. Ivy; Singh, P.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 9 p. 1547 - 1557
反应条件
1: 2.) NaBH4 / 1.) toluene, EtOH, 2.) toluene, EtOH
2: HCl, H2 / Pd(OH)2/C / methanol / 120 h / 2068.6 Torr
View Scheme
参考文献
Brine, George A.; Stark, Peter A.; Liu, Young; Carrol, F. Ivy; Singh, P.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 9 p. 1547 - 1557
参考文献
Burke Jr.; Jacobson; Rice; Silverton; Simonds; Streaty; Klee
Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 1087 - 1093
Title/Abstract Full Text View citing articles Show Details
Brine, George A.; Stark, Peter A.; Liu, Young; Carrol, F. Ivy; Singh, P.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 9 p. 1547 - 1557
Title/Abstract Full Text View citing articles Show Details
Wang; Zhu; Jin; Chen; Ji; Chi
Journal of Medicinal Chemistry, 1995 , vol. 38, # 18 p. 3652 - 3659