2-溴-1,4-二甲氧基-3-甲基-萘合成路线 （共 17 条）
反应条件
1: NaOH / methanol
2: 95 percent / NBS / CH2Cl2 / 0.5 h / 20 °C
View Scheme
参考文献
Jung, Young-Sik; Joe, Bo-Young; Cho, Sung Ju; Konishi, Yasuo
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 4 p. 1125 - 1129
反应条件
1.1: n-BuLi / tetrahydrofuran / -78 °C
1.2: B(OMe)3 / tetrahydrofuran / -78 - 20 °C
2.1: 100 percent / aq. Na2CO3 / Pd(PPh3)4 / 1,2-dimethoxy-ethane; ethanol / 42 h / Heating
View Scheme
参考文献
Pathak, Rakhi; Vandayar, Kantharuby; Van Otterlo, Willem A. L.; Michael, Joseph P.; Fernandes, Manuel A.; De Koning, Charles B.
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 23 p. 3504 - 3509
反应条件
1.1: n-BuLi / tetrahydrofuran / -78 °C
1.2: B(OMe)3 / tetrahydrofuran / -78 - 20 °C
2.1: 100 percent / aq. Na2CO3 / Pd(PPh3)4 / 1,2-dimethoxy-ethane; ethanol / 42 h / Heating
3.1: 81 percent / aq. CAN / acetonitrile / 0.08 h / 20 °C
View Scheme
参考文献
Pathak, Rakhi; Vandayar, Kantharuby; Van Otterlo, Willem A. L.; Michael, Joseph P.; Fernandes, Manuel A.; De Koning, Charles B.
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 23 p. 3504 - 3509
反应条件
2: argentic oxide, PTA / acetonitrile; H2O / 0.5 h
View Scheme
参考文献
Syper, L.; Kloc, K.; Mlochowski, J.
Tetrahedron, 1980 , vol. 36, # 1 p. 123 - 129
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.0833333 h; Inert atmosphere;
2: With tri-isopropoxy-borane in tetrahydrofuran; hexane
T=-78 - 20°C; Inert atmosphere;
3: With hydrogenchloride; water in tetrahydrofuran; hexane
Inert atmosphere;
参考文献
Redondo, Maria C.; Veguillas, Marcos; Ribagorda, Maria; Carreno, M. Carmen
Angewandte Chemie - International Edition, 2009 , vol. 48, # 2 p. 370 - 374
反应条件
(n-butyl)Li in tetrahydrofuran; water
a) (n-butyl)Li, THF, -78°C, b) B(OCH(CH3)2)3, -78°C, c) aq. HCl;
参考文献
Redondo, Maria C.; Veguillas, Marcos; Ribagorda, Maria; Carreno, M. Carmen
Angewandte Chemie - International Edition, 2009 , vol. 48, # 2 p. 370 - 374
反应条件
2: PTA, CAN / acetonitrile; H2O / 0.33 h
View Scheme
参考文献
Syper, L.; Kloc, K.; Mlochowski, J.
Tetrahedron, 1980 , vol. 36, # 1 p. 123 - 129
