5-氯-1,3-二氢-1-(4-哌啶基)-2H-苯并咪唑-2-酮合成路线 （共 8 条）
反应条件
sodium hydroxide 8 h; Heating;
参考文献
Henning; Lattrell; Gerhards; Leven
Journal of Medicinal Chemistry, 1987 , vol. 30, # 5 p. 814 - 820
反应条件
1: Zn; aq. HCl / methanol / 50 °C 2: acetonitrile 3: aq. NaOH / 100 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 19 p. 5052 - 5056
反应条件
1: 65 percent / Na2CO3, KI / various solvent(s) / 28 h / 160 °C 2: 93 percent / H2 / Raney Ni / ethanol; tetrahydrofuran / 1 h / Ambient temperature 3: 90 percent / Et3N / CH2Cl2 / 0.5 h / 0 °C 4: 96 percent / 10percent NaOH / 8 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 5 p. 814 - 820
反应条件
1: 65 percent / Na2CO3, KI / various solvent(s) / 28 h / 160 °C 2: 93 percent / H2 / Raney Ni / ethanol; tetrahydrofuran / 1 h / Ambient temperature 3: 90 percent / Et3N / CH2Cl2 / 0.5 h / 0 °C 4: 96 percent / 10percent NaOH / 8 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 5 p. 814 - 820
反应条件
1: acetonitrile 2: aq. NaOH / 100 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 19 p. 5052 - 5056
反应条件
potassium iodide; sodium carbonate in water
参考文献
Janssen Pharmaceutica N.V.
Patent: US4066772 A1, 1978 ;
反应条件
triethylamine; sodium iodide in N,N-dimethyl-formamide
60 h; Ambient temperature;
参考文献
Henning; Lattrell; Gerhards; Leven
Journal of Medicinal Chemistry, 1987 , vol. 30, # 5 p. 814 - 820
反应条件
sodium hydrogencarbonate in ethanol; chloroform; di-isopropyl ether; water; toluene
参考文献
Janssen Pharmaceutica N.V.
Patent: US3989707 A1, 1976 ;
