4-(2,3-二氢-2-氧代-1H-苯并咪唑-1-基)哌啶-1-羧酸乙酯合成路线 （共 15 条）
反应条件
1: KHMDS / tetrahydrofuran 2: aq. NaOH / ethanol / Heating View Scheme
参考文献
Gustin, Darin J.; Sehon, Clark A.; Wei, Jianmei; Cai, Hui; Meduna, Steven P.; Khatuya, Haripada; Sun, Siquan; Gu, Yin; Jiang, Wen; Thurmond, Robin L.; Karlsson, Lars; Edwards, James P.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 6 p. 1687 - 1691
反应条件
sodium hydroxide in ethanol Heating;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 6 p. 1687 - 1691
反应条件
water; sodium hydrogencarbonate; palladium diacetate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in isopropyl alcohol
T=83°C; 24 h;
参考文献
McLaughlin, Mark; Palucki, Michael; Davies, Ian W.
Organic Letters, 2006 , vol. 8, # 15 p. 3311 - 3314
反应条件
water; sodium hydrogencarbonate; palladium diacetate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in isopropyl alcohol
T=83°C; 72 h;
参考文献
McLaughlin, Mark; Palucki, Michael; Davies, Ian W.
Organic Letters, 2006 , vol. 8, # 15 p. 3311 - 3314
反应条件
water; sodium hydrogencarbonate; palladium diacetate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in isopropyl alcohol
T=83°C; 72 h;
参考文献
McLaughlin, Mark; Palucki, Michael; Davies, Ian W.
Organic Letters, 2006 , vol. 8, # 15 p. 3311 - 3314
反应条件
1: trifluoroacetic acid; sodium triacetoxyborohydride / isopropyl acetate / 0.17 h
2: tetrahydrofuran; isopropyl acetate / 0.5 h / cooling
3: water / tetrahydrofuran; isopropyl acetate / 0.67 h / -10 - 20 °C
4: 89 percent / NaHCO3; H2O / Pd(OAc)2; X-Phos / propan-2-ol / 24 h / 83 °C
View Scheme
参考文献
McLaughlin, Mark; Palucki, Michael; Davies, Ian W.
Organic Letters, 2006 , vol. 8, # 15 p. 3311 - 3314
反应条件
1: trifluoroacetic acid; sodium triacetoxyborohydride / isopropyl acetate / 0.17 h
2: tetrahydrofuran; isopropyl acetate / 0.5 h / cooling
3: water / tetrahydrofuran; isopropyl acetate / 0.67 h / -10 - 20 °C
4: 99 percent Chromat. / NaHCO3; H2O / Pd(OAc)2; X-Phos / propan-2-ol / 72 h / 83 °C
View Scheme
参考文献
McLaughlin, Mark; Palucki, Michael; Davies, Ian W.
Organic Letters, 2006 , vol. 8, # 15 p. 3311 - 3314
反应条件
1: tetrahydrofuran; isopropyl acetate / 0.5 h / cooling
2: water / tetrahydrofuran; isopropyl acetate / 0.67 h / -10 - 20 °C
3: 89 percent / NaHCO3; H2O / Pd(OAc)2; X-Phos / propan-2-ol / 24 h / 83 °C
View Scheme
参考文献
McLaughlin, Mark; Palucki, Michael; Davies, Ian W.
Organic Letters, 2006 , vol. 8, # 15 p. 3311 - 3314
反应条件
1: trifluoroacetic acid; sodium triacetoxyborohydride / isopropyl acetate / 0.17 h
2: tetrahydrofuran; isopropyl acetate / 0.5 h / cooling
3: water / tetrahydrofuran; isopropyl acetate / 0.67 h / -10 - 20 °C
4: 89 percent / NaHCO3; H2O / Pd(OAc)2; X-Phos / propan-2-ol / 24 h / 83 °C
View Scheme
参考文献
McLaughlin, Mark; Palucki, Michael; Davies, Ian W.
Organic Letters, 2006 , vol. 8, # 15 p. 3311 - 3314
反应条件
1: trifluoroacetic acid; sodium triacetoxyborohydride / isopropyl acetate / 0.17 h
2: tetrahydrofuran; isopropyl acetate / 0.5 h / cooling
3: water / tetrahydrofuran; isopropyl acetate / 0.67 h / -10 - 20 °C
4: 70 percent Chromat. / NaHCO3; H2O / Pd(OAc)2; X-Phos / propan-2-ol / 72 h / 83 °C
View Scheme
参考文献
McLaughlin, Mark; Palucki, Michael; Davies, Ian W.
Organic Letters, 2006 , vol. 8, # 15 p. 3311 - 3314
