Amato, Joseph S.; Chung, John Y. L.; Cvetovich, Raymond J.; Gong, Xiaoyi; McLaughlin, Mark; Reamer, Robert A.
Journal of Organic Chemistry, 2005 , vol. 70, # 5 p. 1930 - 1933
1.1: MeI / acetone / 2 h / 25 - 30 °C
1.2: 70.0 g / NaOH; acrylic acid / H2O / 1.5 h / 65 °C
2.1: 99 percent / H2 / Raney-Nickel / ethanol / 2068.59 Torr
View Scheme
参考文献
Amato, Joseph S.; Chung, John Y. L.; Cvetovich, Raymond J.; Gong, Xiaoyi; McLaughlin, Mark; Reamer, Robert A.
Journal of Organic Chemistry, 2005 , vol. 70, # 5 p. 1930 - 1933
1: With thionyl chloride; tetrabutyl-ammonium chloride in toluene
T=85°C;
2: With potassium carbonate in water
T=5°C; pH=11; Title compound not separated from byproducts;
参考文献
Amato, Joseph S.; Chung, John Y. L.; Cvetovich, Raymond J.; Gong, Xiaoyi; McLaughlin, Mark; Reamer, Robert A.
Journal of Organic Chemistry, 2005 , vol. 70, # 5 p. 1930 - 1933
