4,4-四氢吡喃二羧酸二乙酯合成路线 （共 10 条）
反应条件
1: 72 percent / 30percent aq. NaOH / 72 h / Ambient temperature 2: 85 percent / 2 h / 180 °C 3: 91 percent / SOCl2 / 45 h / Heating View Scheme
参考文献
Straessler, Christoph; Linden, Anthony; Heimgartner, Heinz
Helvetica Chimica Acta, 1997 , vol. 80, # 5 p. 1528 - 1551
反应条件
lithium iodide in N,N-dimethyl-formamide
参考文献
Syntex (U.S.A.) Inc.; Agouron Pharmaceuticals, Inc.
Patent: US5932595 A1, 1999 ;
反应条件
1: 88 percent / 10percent aq. HCl / Heating 2: 75 percent / 171 °C 3: 69 percent / 48percent aq. HBr, HBr gas / 12 h / 100 °C 4: 69 percent / PBr3 / 1 h / Heating 5: 68 percent / diethyl ether 6: 41 percent / aq. Na2S / ethanol / 2 h / Heating 7: 60 percent / LiAlH4 / diethyl ether / 4 h / Heating View Scheme
参考文献
Mori, Mitsuo; Takeuchi, Hiroyuki; Minato, Hiroshi; Kobayashi, Michio; Yoshida, Masato; et al.
Phosphorus, Sulfur and Silicon and the Related Elements, 1990 , vol. 47, # 1 + 2 p. 157 - 164
反应条件
1: 72 percent / 30percent aq. NaOH / 72 h / Ambient temperature 2: 85 percent / 2 h / 180 °C View Scheme
参考文献
Mori, Mitsuo; Takeuchi, Hiroyuki; Minato, Hiroshi; Kobayashi, Michio; Yoshida, Masato; et al.
Phosphorus, Sulfur and Silicon and the Related Elements, 1990 , vol. 47, # 1 + 2 p. 157 - 164
反应条件
1: 88 percent / 10percent aq. HCl / Heating 2: 75 percent / 171 °C 3: 69 percent / 48percent aq. HBr, HBr gas / 12 h / 100 °C 4: 69 percent / PBr3 / 1 h / Heating 5: 68 percent / diethyl ether 6: 41 percent / aq. Na2S / ethanol / 2 h / Heating View Scheme
参考文献
Mori, Mitsuo; Takeuchi, Hiroyuki; Minato, Hiroshi; Kobayashi, Michio; Yoshida, Masato; et al.
Phosphorus, Sulfur and Silicon and the Related Elements, 1990 , vol. 47, # 1 + 2 p. 157 - 164
参考文献
Syntex (U.S.A.) LLC
Patent: US6342639 B1, 2002 ;
Location in patent: Scheme D ;
反应条件
hydrogenchloride; Hg; sodium in ethanol
参考文献
Bencherif; Merouane; Lippiello; Patrick M.; Caldwell; William S.
Patent: US5510355 A1, 1996 ;
反应条件
ethanol; sodium ethanolate
参考文献
v. Braun; Koehler
Chemische Berichte, 1917 , vol. 50, p. 1658
反应条件
sodium hydroxide in diethyl ether; water; ethyl acetate
参考文献
AMERSHAM INTERNATIONAL plc
Patent: EP311352 B1, 1991 ;
反应条件
1: With sodium hydroxide in water
T=20°C; 28 h;
2: With hydrogenchloride in water
参考文献
Sumitomo Pharmaceuticals Company, Limited
Patent: EP1514869 A1, 2005 ;
Location in patent: Page/Page column 52 ;
