1-(4-氯苯基)-1,4-戊二酮合成路线 （共 37 条）
反应条件
1: 76 percent / diethyl ether; tetrahydrofuran / 1 h / Heating
2: 12 percent / n-Bu4NCN / tetrahydrofuran / 1.5 h / Ambient temperature
3: 59 percent / DBU / dimethylformamide
4: 98 percent / KCN / dimethylformamide / 0.5 h / Ambient temperature
View Scheme
参考文献
Miyashita, Akira; Suzuki, Yumiko; Okumura, Yoko; Iwamoto, Ken-Ichi; Higashino, Takeo
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 1 p. 6 - 11
反应条件
1: 6 percent / Mn(OAc)2, O2 / acetic acid / 12 h / 23 °C
2: 68 percent / KOH / methanol / 12 h / Heating
3: 84 percent / 2 M aq. HCl / acetic acid / 0.33 h / 80 °C
View Scheme
参考文献
Qian, Chang-Yi; Yamada, Takashi; Nishino, Hiroshi; Kurosawa, Kazu
Bulletin of the Chemical Society of Japan, 1992 , vol. 65, # 5 p. 1371 - 1378
反应条件
1: 68 percent / KOH / methanol / 12 h / Heating
2: 84 percent / 2 M aq. HCl / acetic acid / 0.33 h / 80 °C
View Scheme
参考文献
Qian, Chang-Yi; Yamada, Takashi; Nishino, Hiroshi; Kurosawa, Kazu
Bulletin of the Chemical Society of Japan, 1992 , vol. 65, # 5 p. 1371 - 1378
反应条件
1: 1-(4-chlorophenyl)pent-2-yne-1,4-diol With ruthenium(II)-carbonyl-tris(triphenylphosphine) dihydride; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in toluene
0.5 h; Inert atmosphereReflux;
2: 4-chloro-aniline in toluene
23.5 h; Inert atmosphereReflux;
参考文献
Pridmore, Simon J.; Slatford, Paul A.; Taylor, James E.; Whittlesey, Michael K.; Williams, Jonathan M.J.
Tetrahedron, 2009 , vol. 65, # 44 p. 8981 - 8986
反应条件
1: 1-(4-chlorophenyl)pent-2-yne-1,4-diol With ruthenium(II)-carbonyl-tris(triphenylphosphine) dihydride; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in toluene
0.5 h; Inert atmosphereReflux;
2: aniline in toluene
23.5 h; Inert atmosphereReflux;
参考文献
Pridmore, Simon J.; Slatford, Paul A.; Taylor, James E.; Whittlesey, Michael K.; Williams, Jonathan M.J.
Tetrahedron, 2009 , vol. 65, # 44 p. 8981 - 8986
反应条件
9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in toluene
24 h; Heating; Title compound not separated from byproducts.;
参考文献
Pridmore, Simon J.; Slatford, Paul A.; Daniel, Aurelie; Whittlesey, Michael K.; Williams, Jonathan M.J.
Tetrahedron Letters, 2007 , vol. 48, # 29 p. 5115 - 5120
反应条件
9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in toluene
24 h; Heating; Title compound not separated from byproducts.;
参考文献
Pridmore, Simon J.; Slatford, Paul A.; Daniel, Aurelie; Whittlesey, Michael K.; Williams, Jonathan M.J.
Tetrahedron Letters, 2007 , vol. 48, # 29 p. 5115 - 5120
反应条件
9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in toluene
24 h; Heating; Title compound not separated from byproducts.;
参考文献
Pridmore, Simon J.; Slatford, Paul A.; Daniel, Aurelie; Whittlesey, Michael K.; Williams, Jonathan M.J.
Tetrahedron Letters, 2007 , vol. 48, # 29 p. 5115 - 5120
反应条件
9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in toluene
24 h; Heating; Title compound not separated from byproducts.;
参考文献
Pridmore, Simon J.; Slatford, Paul A.; Daniel, Aurelie; Whittlesey, Michael K.; Williams, Jonathan M.J.
Tetrahedron Letters, 2007 , vol. 48, # 29 p. 5115 - 5120
反应条件
9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in toluene
24 h; Heating; Title compound not separated from byproducts.;
参考文献
Pridmore, Simon J.; Slatford, Paul A.; Daniel, Aurelie; Whittlesey, Michael K.; Williams, Jonathan M.J.
Tetrahedron Letters, 2007 , vol. 48, # 29 p. 5115 - 5120
