2,4-二溴-1-甲基-1H-咪唑合成路线 （共 3 条）
反应条件
ethylmagnesium bromide in tetrahydrofuran T=20°C; 5 h; Inert atmosphere;
参考文献
H. LUNDBECK A/S; KEHLER, Jan; KILBURN, John Paul; NIELSEN, Jacob; PÜSCHL, Ask; LANGGÅRD, Morten; JESSING, Mikkel; MARIGO, Mauro
Patent: WO2013/50527 A1, 2013 ;
Location in patent: Page/Page column 38; 39; 40 ;
反应条件
n-butyllithium; bromine 1.) ether, hexane, -35 deg C, 2.) ether, hexane, -70 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Polish Journal of Chemistry, , vol. 55, # 7/8 p. 1659 - 1665
反应条件
potassium phosphate; palladium diacetate; tris(p-fluoro phenyl)phosphine in tetrahydrofuran
T=80°C; Suzuki coupling; 16 h; Inert atmosphere; regioselective reaction;
参考文献
Strotman, Neil A.; Chobanian, Harry R.; He, Jiafang; Guo, Yan; Dormer, Peter G.; Jones, Christina M.; Steves, Janelle E.
Journal of Organic Chemistry, 2010 , vol. 75, # 5 p. 1733 - 1739
