3-羟基丙脒盐酸盐(1:1)合成路线 （共 4 条）
反应条件
1: 3-hydroxypropanimidamide hydrochloride With sodium in ethanol 0.5 h; 2: 2-chloro-3-(dimethylamino)acrylaldehyde 6 h; Heating;
参考文献
Reiner, Tilman; Kvasyuk, Evgeny; Pfleiderer, Wolfgang
Helvetica Chimica Acta, 2000 , vol. 83, # 11 p. 3053 - 3063
反应条件
thionyl chloride; toluene
参考文献
Price; Zomlefer
Journal of Organic Chemistry, 1949 , vol. 14, p. 213
反应条件
ammonia in methanol
T=0°C; 2.33333 h;
参考文献
3-V BIOSCIENCES, INC.; OSLOB, Johan D.; MCDOWELL, Robert S.; JOHNSON, Russell; YANG, Hanbiao; EVANCHIK, Marc; ZAHARIA, Cristiana A.; CAI, Haiying; HU, Lily W.
Patent: WO2014/8197 A1, 2014 ;
Location in patent: Page/Page column 95 ;
反应条件
hydrogenchloride; methanol; diethyl ether
Umsetzen des Reaktionsprodukts mit NH3 in Metahnol bei 0grad;
参考文献
Price; Zomlefer
Journal of Organic Chemistry, 1949 , vol. 14, p. 213
