3-溴-2,6-二甲基苯胺合成路线 （共 5 条）
反应条件
1: With sodium t-butanolate in toluene T=20°C; 0.5 h; 2: With tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl in toluene T=100°C; 16 h;
参考文献
ENCYSIVE PHARMACEUTICALS INC.
Patent: WO2009/44311 A1, 2009 ;
Location in patent: Page/Page column 39 ;
WO 2009/044311 A1
反应条件
1: (i) NaNO2, aq. H2SO4, (ii) HBF4 2: (i) Mg, THF, (ii) /BRN= 1900390/ 3: (i) SOCl2, (ii) /BRN= 1098229/ View Scheme
参考文献
Hart,H.; Janssen,J.F.
Journal of Organic Chemistry, 1970 , vol. 35, p. 3637 - 3641
反应条件
1: (i) NaNO2, aq. H2SO4, (ii) HBF4 2: (i) Mg, THF, (ii) /BRN= 1900390/ 3: (i) SOCl2, (ii) /BRN= 1098229/ 4: LiAlH4 / diethyl ether 5: SOCl2 6: LiAlH4 / tetrahydrofuran View Scheme
参考文献
Hart,H.; Janssen,J.F.
Journal of Organic Chemistry, 1970 , vol. 35, p. 3637 - 3641
反应条件
1: (i) NaNO2, aq. H2SO4, (ii) HBF4 2: (i) Mg, THF, (ii) /BRN= 1900390/ View Scheme
参考文献
Hart,H.; Janssen,J.F.
Journal of Organic Chemistry, 1970 , vol. 35, p. 3637 - 3641
反应条件
(i) NaNO2, aq. H2SO4, (ii) HBF4; Multistep reaction;
参考文献
Hart,H.; Janssen,J.F.
Journal of Organic Chemistry, 1970 , vol. 35, p. 3637 - 3641
