5-羟基-4-氧代-4H-色烯-2-羧酸合成路线 （共 7 条）
反应条件
hydrogen bromide; acetic acid
T=100°C; 2 h;
参考文献
Hadjeri, Mohamed; Barbier, Magali; Ronot, Xavier; Mariotte, Anne-Marie; Boumendjel, Ahcene; Boutonnat, Jean
Journal of Medicinal Chemistry, 2003 , vol. 46, # 11 p. 2125 - 2131
反应条件
hydrogenchloride in water; acetic acid
T=80°C; 3 h; Heating / reflux;
参考文献
MERCK PATENT GmbH
Patent: EP1426378 A1, 2004 ;
Location in patent: Page 21 ;
反应条件
1: 98 percent / K2CO3 / acetone / 4 h / Heating
2: 71 percent / EtONa / ethanol / 10 h / 100 °C
3: 90 percent / aq. NaHCO3 / 3 h / 80 °C
4: 87 percent / HBr; AcOH / 2 h / 100 °C
View Scheme
参考文献
Hadjeri, Mohamed; Barbier, Magali; Ronot, Xavier; Mariotte, Anne-Marie; Boumendjel, Ahcene; Boutonnat, Jean
Journal of Medicinal Chemistry, 2003 , vol. 46, # 11 p. 2125 - 2131
反应条件
1: 71 percent / EtONa / ethanol / 10 h / 100 °C
2: 90 percent / aq. NaHCO3 / 3 h / 80 °C
3: 87 percent / HBr; AcOH / 2 h / 100 °C
View Scheme
参考文献
Hadjeri, Mohamed; Barbier, Magali; Ronot, Xavier; Mariotte, Anne-Marie; Boumendjel, Ahcene; Boutonnat, Jean
Journal of Medicinal Chemistry, 2003 , vol. 46, # 11 p. 2125 - 2131
反应条件
diethyl ether; sodium ethanolate; xylene
Erhitzen des Reaktionsprodukts mit Essigsaeure und konz. Salzsaeure;
参考文献
Jarowski et al.
Journal of the American Chemical Society, 1949 , vol. 71, p. 944
反应条件
1: 90 percent / aq. NaHCO3 / 3 h / 80 °C
2: 87 percent / HBr; AcOH / 2 h / 100 °C
View Scheme
参考文献
Hadjeri, Mohamed; Barbier, Magali; Ronot, Xavier; Mariotte, Anne-Marie; Boumendjel, Ahcene; Boutonnat, Jean
Journal of Medicinal Chemistry, 2003 , vol. 46, # 11 p. 2125 - 2131
参考文献
Jarowski et al.
Journal of the American Chemical Society, 1949 , vol. 71, p. 944
