sodium hydroxide in methanol T=0 - 20°C; 2 h;

1: N-(carbobenzyloxy)-glycine With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in N,N-dimethyl-formamide T=0°C; 0.166667 h; 2: (S)-(-)-tryptophan methyl ester hydrochloride With 4-methyl-morpholine in N,N-dimethyl-formamide T=0 - 20°C; pH=8;

1.1: thionyl chloride / Reflux 2.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.17 h / 0 °C 2.2: 0 - 20 °C / pH 8 View Scheme