反应条件
1: 1.) DMSO, oxalyl chloride, 2.) Et3N / 1.) THF, -78 deg C, 1 h, 2.) THF, a) -78 deg C, 45 min, b) RT, 1 h
2: 1.) NaH / 1.) THF, 0 deg C, 30 min, 2.) THF, 0 deg C, 1 h
3: 96 percent / diisobutylaluminum hydride (DIBAL) / tetrahydrofuran; hexane / 0.25 h / 0 °C
4: 81 percent / pyridinium p-toluenesulfonate (PPTS) / CH2Cl2 / Ambient temperature
5: 1.) n-butyllithium / 1.) THF, hexane, -78 deg C, 1.5 h, 2.) THF, hexane, a) -78 deg C, 1 h, b) RT, 1 h
6: 1.) cuprous iodide / 1.) THF, ether, 0 deg C, 30 min, 2.) THF, ether, -78 deg C, 2 h
7: 95 percent / Amberlyst-15 resin (H+ form), methanol / 3 h / Ambient temperature
View Scheme
参考文献
Smith III, Amos B.; Leahy, James W.; Noda, Ichio; Remiszewski, Stacy W.; Liverton, Nigel J.; Zibuck, Regina
Journal of the American Chemical Society, 1992 , vol. 114, # 8 p. 2995 - 3007
