4-氯-2-(三氟甲基)苯酚合成路线 （共 6 条）
反应条件
1: With sulfuric acid; sodium nitrite in water
T=0°C; 3 h;
2: With urea in water
1.16667 h; Heating / reflux;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/92835 A1, 2005 ;
Location in patent: Page/Page column 37 ;
WO 2005/092835 A1
反应条件
1: With hydrogenchloride; sodium nitrite in water; acetonitrile
T=0°C; 0.5 h;
2: With copper(l) chloride in water; acetonitrile
T=100°C; 6 h;
参考文献
GLAXO GROUP LIMITED; WANG, Yonghui; YANG, Ting
Patent: WO2012/100734 A1, 2012 ;
Location in patent: Page/Page column 28-29 ;
WO 2012/100734 A1
反应条件
hydrogenchloride; potassium hydroxide in dimethyl sulfoxide; tert-butyl alcohol
参考文献
Rohm and Haas Company
Patent: US4259510 A1, 1981 ;
反应条件
biscyclopentadienyliron(II); sulfuric acid; dihydrogen peroxide in water; dimethyl sulfoxide
参考文献
Kino, Tatsuhito; Nagase, Yu; Ohtsuka, Yuhki; Yamamoto, Kyoko; Uraguchi, Daisuke; Tokuhisa, Kenji; Yamakawa, Tetsu
Journal of Fluorine Chemistry, 2010 , vol. 131, # 1 p. 98 - 105
反应条件
1.1: lithium chloride / N,N-dimethyl-formamide / 5 h / 160 °C
1.2: 20 °C
2.1: zinc; ammonium formate / water; methanol / 3 h / 80 °C
3.1: hydrogenchloride; sodium nitrite / acetonitrile; water / 0.5 h / 0 °C
3.2: 6 h / 100 °C
View Scheme
参考文献
GLAXO GROUP LIMITED; WANG, Yonghui; YANG, Ting
Patent: WO2012/100734 A1, 2012 ;
WO 2012/100734 A1
反应条件
1.1: zinc; ammonium formate / water; methanol / 3 h / 80 °C
2.1: hydrogenchloride; sodium nitrite / acetonitrile; water / 0.5 h / 0 °C
2.2: 6 h / 100 °C
View Scheme
参考文献
GLAXO GROUP LIMITED; WANG, Yonghui; YANG, Ting
Patent: WO2012/100734 A1, 2012 ;
WO 2012/100734 A1
