1: 4-bromo-phenol With di-isopropyl azodicarboxylate; triphenylphosphine; Wang resin in tetrahydrofuran T=20°C; 2: 2,5-dichloro-phenylboronic acid With sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; water T=80°C; Suzuki reaction; 3: With trifluoroacetic acid in dichloromethane 0.166667 h;