(S)-2-(2-吡咯烷基)乙酸甲酯合成路线 （共 9 条）
反应条件
hydrogen; palladium dihydroxide in methanol
T=20°C; P=760 Torr; 1 h;
参考文献
Calvet, Sandrine; David, Olivier; Vanucci-Bacque, Corinne; Fargeau-Bellassoued, Marie-Claude; Lhommet, Gerard
Tetrahedron, 2003 , vol. 59, # 33 p. 6333 - 6339
反应条件
chloro-trimethyl-silane
T=20°C; 15 h;
参考文献
NOVARTIS AG; DECHANTSREITER, Michael A.; GROB, Jonathan E.; MAC SWEENEY, Aengus; MILTZ, Wolfgang; RANDL, Stefan; SEDRANI, Richard; SELLNER, Holger; SIROCKIN, Finton; VALEUR, Eric
Patent: WO2013/192345 A1, 2013 ;
Location in patent: Page/Page column 103 ;
反应条件
trifluoroacetic acid in dichloromethane
T=0 - 20°C; Substitution; 1.75 h;
参考文献
Harrison, Justin R.; O'Brien, Peter; Porter, David W.; Smith, Neil M.
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 24 p. 3623 - 3631
反应条件
1: 66 percent / NaH; n-BuLi / tetrahydrofuran; hexane / 15 h / -30 °C
2: 57 percent / I2; Na2HPO4; Na2SO4 / 65 °C
3: 53 percent / H2 / PtO2 / methyl acetate / 24 h / 20 °C / 760 Torr
4: 70 percent / H2 / Pd(OH)2/C / methanol / 1 h / 20 °C / 760 Torr
View Scheme
参考文献
Calvet, Sandrine; David, Olivier; Vanucci-Bacque, Corinne; Fargeau-Bellassoued, Marie-Claude; Lhommet, Gerard
Tetrahedron, 2003 , vol. 59, # 33 p. 6333 - 6339
反应条件
1: 53 percent / H2 / PtO2 / methyl acetate / 24 h / 20 °C / 760 Torr
2: 70 percent / H2 / Pd(OH)2/C / methanol / 1 h / 20 °C / 760 Torr
View Scheme
参考文献
Calvet, Sandrine; David, Olivier; Vanucci-Bacque, Corinne; Fargeau-Bellassoued, Marie-Claude; Lhommet, Gerard
Tetrahedron, 2003 , vol. 59, # 33 p. 6333 - 6339
反应条件
1: 57 percent / I2; Na2HPO4; Na2SO4 / 65 °C
2: 53 percent / H2 / PtO2 / methyl acetate / 24 h / 20 °C / 760 Torr
3: 70 percent / H2 / Pd(OH)2/C / methanol / 1 h / 20 °C / 760 Torr
View Scheme
参考文献
Calvet, Sandrine; David, Olivier; Vanucci-Bacque, Corinne; Fargeau-Bellassoued, Marie-Claude; Lhommet, Gerard
Tetrahedron, 2003 , vol. 59, # 33 p. 6333 - 6339
反应条件
1: Et3N / diethyl ether / -20 - 0 °C
2: diethyl ether / 16 h / 20 °C
3: 99 percent / PhCOOAg; Et3N / 3 h / -25 - 20 °C
4: 16 percent / TFA / CH2Cl2 / 1.75 h / 0 - 20 °C
View Scheme
参考文献
Harrison, Justin R.; O'Brien, Peter; Porter, David W.; Smith, Neil M.
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 24 p. 3623 - 3631
反应条件
1: diethyl ether / 16 h / 20 °C
2: 99 percent / PhCOOAg; Et3N / 3 h / -25 - 20 °C
3: 16 percent / TFA / CH2Cl2 / 1.75 h / 0 - 20 °C
View Scheme
参考文献
Harrison, Justin R.; O'Brien, Peter; Porter, David W.; Smith, Neil M.
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 24 p. 3623 - 3631
反应条件
1: 99 percent / PhCOOAg; Et3N / 3 h / -25 - 20 °C
2: 16 percent / TFA / CH2Cl2 / 1.75 h / 0 - 20 °C
View Scheme
参考文献
Harrison, Justin R.; O'Brien, Peter; Porter, David W.; Smith, Neil M.
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 24 p. 3623 - 3631
