1-(4-甲氧基苯基)-2-丁酮合成路线 （共 26 条）
反应条件
sodium methylate in benzene Heating;
参考文献
Fontaine,L. et al.
Chimica Therapeutica, 1967 , vol. 2, p. 430 - 440
反应条件
Dess-Martin periodane in dichloromethane
T=20°C; 0.5 h;
参考文献
JE IL PHARMACEUTICAL CO., LTD.
Patent: WO2007/102679 A1, 2007 ;
Location in patent: Page/Page column 113 ;
WO 2007/102679 A1
反应条件
sulfuric acid; toluene-4-sulfonic acid in methanol
T=0 - 5°C; ceramic diaphragm, carbon-rod anode, platinum cathode, 4.5 F/mol, 0.1A, cathode potential -1.45 to -1.65V vs. SCE;
参考文献
Shono, Tatsuya; Hamaguchi, Hiroshi; Mikami, Hiroshi; Nogusa, Hideo; Kashimura, Shigenori
Journal of Organic Chemistry, 1983 , vol. 48, # 12 p. 2103 - 2105
反应条件
in tetrahydrofuran
T=0 - 20°C;
参考文献
Ghosh, Usha; Ganessunker, Deshanie; Sattigeri, Viswajanani J.; Carlson, Kathryn E.; Mortensen, Deborah J.; Katzenellenbogen, Benita S.; Katzenellenbogen, John A.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 4 p. 629 - 657
反应条件
1: aq. NaOH / ethanol / 4 h / Heating
2: 11.553 g / 5 h / 60 - 100 °C
View Scheme
参考文献
Clegg, Nicola J.; Paruthiyil, Sreenivasan; Leitman, Dale C.; Scanlan, Thomas S.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 5989 - 6003
反应条件
1.1: lithium hexamethyl-disilazide / tetrahydrofuran / 0.5 h / -78 °C
1.2: tetrahydrofuran / 2 h / -78 - 25 °C
2.1: aq. NaOH / ethanol / 4 h / Heating
3.1: 11.553 g / 5 h / 60 - 100 °C
View Scheme
参考文献
Clegg, Nicola J.; Paruthiyil, Sreenivasan; Leitman, Dale C.; Scanlan, Thomas S.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 5989 - 6003
反应条件
hydrogenchloride
T=160°C;
参考文献
v. Wessely et al.
Monatshefte fuer Chemie, 1941 , vol. 73, p. 127,158
反应条件
1: 100 percent / pyridine / CH2Cl2 / 1 h / 20 °C
2: 81 percent / tetrahydrofuran / 0 - 20 °C
View Scheme
参考文献
Ghosh, Usha; Ganessunker, Deshanie; Sattigeri, Viswajanani J.; Carlson, Kathryn E.; Mortensen, Deborah J.; Katzenellenbogen, Benita S.; Katzenellenbogen, John A.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 4 p. 629 - 657
反应条件
hydrogenchloride
T=160°C;
参考文献
v. Wessely et al.
Monatshefte fuer Chemie, 1941 , vol. 73, p. 127,158
参考文献
Clegg, Nicola J.; Paruthiyil, Sreenivasan; Leitman, Dale C.; Scanlan, Thomas S.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 19 p. 5989 - 6003
