2,4,5,6-四氨基嘧啶硫酸盐合成路线 （共 25 条）
反应条件
triethylamine in water; N,N-dimethyl-formamide T=20°C; 264 h;
参考文献
Zav'yalov, S. I.; Zavozin, A. G.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1981 , vol. 30, # 7 p. 1355 - 1357
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1981 , # 7 p. 1666 - 1668
反应条件
BaCl2 in water T=85 - 90°C; 0.25 h;
参考文献
Kamen, Barton; Cole, Peter; Smith, Angela; Zebala, John A.
Patent: US2005/209239 A1, 2005 ;
Location in patent: Page/Page column 16 ;
反应条件
1: 2,4,5,6-tetraaminopyrimidine sulphate With BaCl2 in water T=100°C; 0.166667 h; 2: 1.3-dihydroxypropan-2-one With sodium acetate; dl-cysteine hydrochloride in water T=20°C; 24 h;
参考文献
BIORELIX, INC.; COISH, Philip, D., G.; WICKENS, Phil; DIXON, Brian; OSTERMAN, David; KHIRE, Uday, R.; NAVIA, Manuel; BERMAN, Judd; KAUR, Harpreet; WILSON, Jeffrey; UNDERWOOD, Dennis
Patent: WO2010/110907 A1, 2010 ;
Location in patent: Page/Page column 48-49 ;
WO 2010/110907 A1
反应条件
selenium(IV) oxide; sodium acetate in water
参考文献
Institutul Oncologic
Patent: US3989703 A1, 1976 ;
反应条件
1: 2,4,5,6-tetraaminopyrimidine sulphate With BaCl2 in water T=90°C; 0.25 h; 2: L-cysteine monohydrochloride powder With ammonium hydroxide; oxygen; ammonium chloride in water T=5°C; 0.25 h; 3: With 1,3-dihydroxy-2-propanone-dimer; oxygen in water T=5 - 20°C; 48 h; Further stages.;
参考文献
Valiaeva; Bartley; Konno; Coward
Journal of Organic Chemistry, 2001 , vol. 66, # 15 p. 5146 - 5154
反应条件
PPA; Polyphosphoric acid (PPA) T=170°C; 1 h;
参考文献
Young, Rodney C.; Jones, Martin; Milliner, Kevin J.; Rana, Kishore K.; Ward, John G.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 8 p. 2073 - 2080
反应条件
ammonium hydroxide; L-cysteine monohydrochloride powder; oxygen; ammonium chloride; BaCl2 1.) H2O, 90 deg C, 15 min, 2.) H2O, RT, 45 h; Yield given. Multistep reaction;
参考文献
Rosowsky; Freisheim; Bader; Forsch; Susten; Cucchi
Journal of Medicinal Chemistry, 1985 , vol. 28, # 5 p. 660 - 667
反应条件
sodium hydrogencarbonate in diethyl ether; water
参考文献
TargeGen, Inc.
Patent: US2005/282814 A1, 2005 ;
反应条件
piperidine; potassium hydroxide 1.) water, 20 deg C, 7 d, 2.) heating; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Zav'yalov, S. I.; Zavozin, A. G.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1981 , vol. 30, # 7 p. 1355 - 1357
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1981 , # 7 p. 1666 - 1668
反应条件
sodium hydroxide; sodium hydrogensulfite in water
参考文献
Lonza Ltd.
Patent: US4224446 A1, 1980 ;
