1-溴-4,5-二甲基-2-硝基苯合成路线 (共 4 条)
反应条件
1: With sodium dithionite in 2-methoxy-ethanol; water T=100°C; 2.5 h; 2: With hydrogenchloride in 2-methoxy-ethanol; water 0.416667 h; Heating / reflux; 3: With sodium carbonate in 2-methoxy-ethanol; water T=20°C; pH=~ 7 - ~ 8;
参考文献
TEIJIN LIMITED
Patent: EP1502916 A1, 2005 ;
Location in patent: Page 463-464 ;
EP 1502916 A1
反应条件
1: With hydrogen bromide
T=70°C; 0.5 h;
2: With sodium nitrite
T=-5°C; 0.25 h;
3: With hydrogen bromide; copper(I) bromide
T=-5 - 70°C; 0.25 h;
参考文献
Langner, Martin; Remy, Pauline; Bolm, Carsten
Chemistry - A European Journal, 2005 , vol. 11, # 21 p. 6254 - 6265
反应条件
sodium bromide; hydrogen bromide; sodium sulfite; sodium nitrite in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; sulfuric acid; water; acetic acid
参考文献
Schering Aktiengesellschaft
Patent: US4411910 A1, 1983 ;
反应条件
nitric acid; acetic anhydride
参考文献
Blackstock,D.J. et al.
Journal of the Chemical Society [Section] B: Physical Organic, 1971 , p. 1212 - 1213