反应条件
1: 10 percent / sodium tert-butoxide / 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl; tris(dibenzylideneacetone)dipalladium(0) / toluene / 5 h / 80 - 85 °C
2: H2 / Pd/C / ethyl acetate / 3 h / 760.05 Torr
3: 19 mg / trifluoroacetic acid / CH2Cl2 / 0.5 h
View Scheme
参考文献
Bunnelle, William H.; Daanen, Jerome F.; Ryther, Keith B.; Schrimpf, Michael R.; Dart, Michael J.; Gelain, Arianna; Meyer, Michael D.; Frost, Jennifer M.; Anderson, David J.; Buckley, Michael; Curzon, Peter; Cao, Ying-Jun; Puttfarcken, Pamela; Searle, Xenia; Ji, Anguo; Putman, C. Brent; Surowy, Carol; Toma, Lucio; Barlocco, Daniela
Journal of Medicinal Chemistry, 2007 , vol. 50, # 15 p. 3627 - 3644