N-(4-溴丁基)邻苯二甲酰亚胺合成路线 （共 50 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=100°C; 8 h;
参考文献
AUCKLAND UNISERVICES LIMITED
Patent: WO2006/104406 A1, 2006 ;
Location in patent: Page/Page column 172-173 ;
反应条件
aq NaOH in methanol; dichloromethane
参考文献
SmithKline Beecham Corporation
Patent: US5593992 A1, 1997 ;
反应条件
aq NaOH in methanol; dichloromethane
参考文献
SmithKline Beecham Corporation
Patent: US5670527 A1, 1997 ;
反应条件
1: With triethylamine in ethanol 6 h; Heating / reflux; 2: With ethanol; hydrazine 2 h; Heating / reflux;
参考文献
GLAXO GROUP LIMITED
Patent: WO2009/71576 A1, 2009 ;
Location in patent: Page/Page column 24 ;
WO 2009/071576 A1
反应条件
hydrogen bromide; acetic acid
参考文献
Klayman; Grenan; Jacobus
Journal of medicinal chemistry, 1969 , vol. 12, # 3 p. 510 - 512
反应条件
benzene Kochen des Reaktionsprodukts mit konz.wss.HCl;
参考文献
Chavane
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1947 , vol. 224, p. 406,407
Annales de Chimie (Cachan, France), 1949 , vol. <12>4, p. 377
反应条件
in water; ethylenediamine; butan-1-ol
参考文献
Pierre Fabre Medicament
Patent: US6303603 B1, 2001 ;
反应条件
hydrazine hydrate Multistep reaction;
参考文献
He, Xiao Shu; Woodruff, Kristine; Brodbeck, Robbin
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 18 p. 2399 - 2402
反应条件
sodium hydroxide; potassium carbonate; hydrazine hydrate in ethanol; water; ethyl acetate; N,N-dimethyl-formamide
参考文献
Andersen, Knud Erik; Dorwald, Florencio Zaragiza; Peschke, Bernd; Sidelmann, Ulla Grove; Rudolf, Klaus; Stenkamp, Dirk; Hurnaus, Rudolf; Muller, Stephan Georg; Krist, Bernd; Eriksen, Birgitte
Patent: US2002/58659 A1, 2002 ;
US 20020058659 A1
反应条件
1: sodium ethylate; ethanol 2: acetone; water; hydrogen peroxide View Scheme
参考文献
Moriarty, Robert M.; Naithani, Rajesh; Kosmeder, Jerome; Prakash, Om
European Journal of Medicinal Chemistry, 2006 , vol. 41, # 1 p. 121 - 124
