2,2,6-三甲基-4H-1,3-二英-4-酮合成路线 （共 203 条）
参考文献
Sato, Masayuki; Ogasawara, Hiromischi; Kato, Keiko; Sakai, Masako; Kato, Tetsuzo
Chemical & Pharmaceutical Bulletin, 1983 , vol. 31, # 12 p. 4300 - 4305
反应条件
in xylene
T=150°C; Acylation; 0.666667 h;
参考文献
Robert-Piessard; Duval; Seraphin; Robert; Nourrisson; Le Baut; Grimaud
Pharmaceutical Sciences, 1997 , vol. 3, # 5-6 p. 295 - 299
反应条件
1: 2,2,6-trimethyl-4H-1,3-dioxin-4-one With lithium diisopropyl amide in tetrahydrofuran
T=-78°C; 1.75 h;
2: PhCOBt in tetrahydrofuran
T=-78 - 20°C;
参考文献
Katritzky, Alan R.; Wang, Zuoquan; Wang, Mingyi; Hall, C. Dennis; Suzuki, Kazuyuki
Journal of Organic Chemistry, 2005 , vol. 70, # 12 p. 4854 - 4856
反应条件
1: 2,2,6-trimethyl-4H-1,3-dioxin-4-one With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane
T=-78°C; 0.5 h; Inert atmosphere;
2: benzoyl chloride in tetrahydrofuran; hexane
T=-78 - -40°C; 2 h; Inert atmosphere;
参考文献
Peixoto, Philippe Alexandre; Boulange, Agathe; Leleu, Stephane; Franck, Xavier
European Journal of Organic Chemistry, 2013 , # 16 p. 3316 - 3327
反应条件
1: 2,2,6-trimethyl-4H-1,3-dioxin-4-one With dihydroxy-poly(ethylene glycol) of MW = 4000 in toluene
5 h; Heating;
2: 3-methyl-phenol With titanium tetrachloride in tetrahydrofuran
T=20°C; von Pechmann reaction; 0.583333 h;
参考文献
Sheng, Shou-Ri; Huang, Pei-Gang; Wang, Qiong; Huang, Ren; Liu, Xiao-Ling
Synthetic Communications, 2006 , vol. 36, # 21 p. 3175 - 3181
反应条件
in anhydrous xylene
Reflux;
参考文献
Razzaghi-Asl, Nima; Firuzi, Omidreza; Hemmateenejad, Bahram; Javidnia, Katayoun; Edraki, Najmeh; Miri, Ramin
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 22 p. 6893 - 6909
反应条件
in xylene
2 h; Heatingalso with other heterocyclic amines, azido-, and chloroacetamide; also in 2-methoxyethyl ether by heating in a microwave oven 4 times for 20 s;
参考文献
Zupet; Tisler; Golic
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 7 p. 1731 - 1740
反应条件
T=150°C; 0.5 h; Green chemistry;
参考文献
Shaabani, Ahmad; Seyyedhamzeh, Mozhdeh; Ganji, Nasim; Ng, Seik Weng
Journal of the Iranian Chemical Society, 2014 , vol. 11, # 2 p. 481 - 487
反应条件
in anhydrous xylene
Reflux;
参考文献
Razzaghi-Asl, Nima; Firuzi, Omidreza; Hemmateenejad, Bahram; Javidnia, Katayoun; Edraki, Najmeh; Miri, Ramin
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 22 p. 6893 - 6909
反应条件
in xylene
1 h; Heating;
参考文献
Doyle, Michael P.; Dyatkin, Alexey B.
Journal of Organic Chemistry, 1995 , vol. 60, # 10 p. 3035 - 3038
