(R)-(+)-α-甲基缬氨酸合成路线 （共 9 条）
反应条件
hydrogen bromide in 1,4-dioxane 3 h; Heating;
参考文献
Branca, Mathieu; Gori, Didier; Guillot, Regis; Alezra, Valerie; Kouklovsky, Cyrille
Journal of the American Chemical Society, 2008 , vol. 130, # 18 p. 5864 - 5865
反应条件
1: With hydrogen bromide in water RefluxInert atmosphere; 2: With Dowex-H+ Inert atmosphere;
参考文献
Branca, Mathieu; Pena, Sebastien; Guillot, Regis; Gori, Didier; Alezra, Valerie; Kouklovsky, Cyrille
Journal of the American Chemical Society, 2009 , vol. 131, # 30 p. 10711 - 10718
反应条件
10 Pd on charcoal; cyclohexene in ethanol 1 h; Reflux;
参考文献
Levine, Mindy; Kenesky, Craig Scott; Mazori, Daniel; Breslow, Ronald
Organic Letters, 2008 , vol. 10, # 12 p. 2433 - 2436
反应条件
in water T=37°C; Ochrobactrum anthropi NCIMB 40321;
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 114, # 4-5 p. 231 - 238
反应条件
1: LDA / tetrahydrofuran; hexane / 0.5 h / -78 °C 2: tetrahydrofuran; hexane / 2 h / -78 - 0 °C 3: 1.) 6 N HCl, 2.) Dowex 50 WX / 1.) water, 175 deg C to 185 deg C, 4 h; 2.) water View Scheme
参考文献
Helvetica Chimica Acta, , vol. 68, p. 144 - 154
反应条件
sodium hydroxide (enzymatic transformation);
参考文献
The Journal of organic chemistry, , vol. 40, # 7 p. 953 - 955
反应条件
T=37°C; Mycobacterium neoarum ATCC 25795, pH 8-8.5; Yield given;
参考文献
Tetrahedron Asymmetry, , vol. 4, # 6 p. 1113 - 1116
反应条件
hydrogenchloride; Dowex 50 WX 1.) water, 175 deg C to 185 deg C, 4 h; 2.) water; Yield given. Multistep reaction;
参考文献
Helvetica Chimica Acta, , vol. 68, p. 144 - 154
反应条件
chloro-trimethyl-silane; N-ethyl-N,N-diisopropylamine
1.) CH2Cl2, 60 deg C, 1 h, 2.) CH2Cl2, 50 deg C, 2 h; Multistep reaction;
参考文献
Obrecht; Bohdal; Broger; Bur; Lehmann; Ruffieux; Schonholzer; Spiegler; Muller
Helvetica Chimica Acta, 1995 , vol. 78, # 3 p. 563 - 580
