2-(6-溴己氧基)四氢-2H-吡喃合成路线 （共 75 条）
反应条件
carbon tetrabromide; triphenylphosphine
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 11 p. 1365 - 1370
反应条件
2: CBr3, PPh3 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 11 p. 1365 - 1370
反应条件
iodine; magnesium; ethylene dibromide 1.) 2-methyltetrahydrofuran, 45 min, 2.) - 15 deg C - room temperature, 120 min; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Poppe; Recseg; Novak
Synthetic Communications, 1995 , vol. 25, # 24 p. 3993 - 4000
反应条件
1: 58 percent / Li2CuCl4 / tetrahydrofuran / 4 h / -78 °C 2: 70 percent / PDC / dimethylformamide / 18 h View Scheme
参考文献
Hassarajani, S. A.; Mithran, S.; Mamdapur, V. R.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1995 , vol. 34, # 5 p. 429 - 431
反应条件
iodine; magnesium; ethylene dibromide 1.) 2-methyltetrahydrofuran, 45 min, 2.) - 15 deg C - room temperature, 120 min; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Poppe; Recseg; Novak
Synthetic Communications, 1995 , vol. 25, # 24 p. 3993 - 4000
反应条件
1: 1.) n-BuLi / 1.) THF, hexane, -10 deg C, 3,5 h, 2.) THF, hexane, -10 deg C, 4 h 2: 87 percent / Raney nickel / 5 h / Heating View Scheme
参考文献
Deshmukh; Veeresh
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1996 , vol. 35, # 12 p. 1239 - 1241
反应条件
sodium hydroxide; potassium iodide in ethanol; water T=80°C; 7.5 h;
参考文献
DAINIPPON INK AND CHEMICALS, INC.
Patent: EP1174412 A1, 2002 ;
Location in patent: Page 84 ;
反应条件
1: 1.) Mg, I2, 2.) Li2CuCl4 / 1.) Et2O, reflux, 2 h, 2.) THF, Et2O, a) -78 deg C, 4 h, b) RT, overnight 2: p-toluenesulphonic acid / methanol / 2 h / 50 °C View Scheme
参考文献
Popovici, Nicolae
Revue Roumaine de Chimie, 1997 , vol. 42, # 3 p. 221 - 224
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0.17 h / 0 °C 1.2: hexamethylphosphoric triamide (HMPA) / tetrahydrofuran; hexane / 22 h / 20 °C 2.1: 47.7 g / D-10-camphorsulfonic acid / methanol / 24 h / 20 °C 3.1: H2 / Lindlar's catalyst / hexane / 9 h / 20 °C 4.1: 8.7 g / (COCl)2; DMSO; Et3N / CH2Cl2 / 1 h / 0 °C 5.1: 96 percent / NaClO2; 2-methyl-2-butene; aq. NaH2PO4 / 2-methyl-propan-2-ol / 3 h / 20 °C View Scheme
参考文献
Singh, Arti A.; Zulkifli, Siti N.A.; Meyns, Michaela; Hayes, Patricia Y.; De Voss, James J.
Tetrahedron Asymmetry, 2011 , vol. 22, # 18-19 p. 1709 - 1719
反应条件
1: 1) NaH / 1) THF, RT, 10 min, 2) THF, 70 deg C, 10 h 2: 99.4 percent / KOH / ethanol / 30 h / Ambient temperature 3: 1) NaH / 1) THF, Rt, 30 min, 2) THF, 24 h, 70 deg C 4: 72.3 percent / Na2EDTA, NaHCO3, Oxone, MeCOCF3 / acetonitrile / 0.5 h / 0 °C 5: 76.6 percent / pyridinium p-toluenesulfonate / ethanol / 3 h / 55 °C 6: 80.4 percent / PPh3, DEAD / tetrahydrofuran / 2 h / Ambient temperature View Scheme
参考文献
Suh, Young-Ger; Min, Kyung-Hoon; Back, So-Young; Chai, Jung-Hyeon
Heterocycles, 1998 , vol. 48, # 8 p. 1527 - 1535
