2-(6-溴己氧基)四氢-2H-吡喃合成路线 （共 75 条）
反应条件
lithium amide; ammonia in tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide T=-30°C; 7 h;
参考文献
Venkateswara Rao; Kumar, V. Satish; Nagarajan; Sitaramaiah; Rama Rao
Tetrahedron Letters, 1996 , vol. 37, # 47 p. 8613 - 8616
反应条件
lithium amide in tetrahydrofuran; ammonia
参考文献
Binisti, Carine; Assogba, Leon; Touboul, Estera; Mounier, Carine; Huet, Jack; Ombetta, Jean-Edouard; Dong, Chang Zhi; Redeuilh, Catherine; Heymans, Francoise; Godfroid, Jean-Jacques
European Journal of Medicinal Chemistry, 2001 , vol. 36, # 10 p. 809 - 828
反应条件
1.1: magnesium / tetrahydrofuran / Heating 1.2: Li2CuCl4 / tetrahydrofuran / -20 °C 2.1: 2,4,4,6-tetrabromocyclohexa-2,5-dienone; PPh3 / CH2Cl2 View Scheme
参考文献
Mohr, Wolfgang; Horn, Clemens R.; Stahl, Juergen; Gladysz
Synthesis, 2003 , # 8 p. 1279 - 1285
反应条件
N,N'-dimethyl-N,N'-propyleneurea; n-butyllithium in tetrahydrofuran; hexane T=0°C; Alkylation;
参考文献
Svatos, Ales; Attygalle, Athula B.; Jham, Gulab N.; Frighetto, Rosa T. S.; Vilela, Evaldo F.; Saman, David; Meinwald, Jerrold
Journal of Chemical Ecology, 1996 , vol. 22, # 4 p. 787 - 800
反应条件
iodine; magnesium; ethylene dibromide 1.) 2-methyltetrahydrofuran, 45 min, 2.) - 15 deg C - room temperature, 120 min; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Poppe; Recseg; Novak
Synthetic Communications, 1995 , vol. 25, # 24 p. 3993 - 4000
反应条件
iodine in tetrahydrofuran 0.75 h; Heating / reflux;
参考文献
MARTEK BIOSCIENCES CORPORATION; RAMAN, Krishna; TARWADE, Vinod; SALEM, Norman, Jr.
Patent: WO2011/53892 A1, 2011 ;
Location in patent: Page/Page column 45 ;
反应条件
magnesium in tetrahydrofuran
参考文献
Hahn,S.; Stoilov,I.L.; Tam Ha,T.B.
Journal of the American Chemical Society, 1988 , vol. 110, p. 8117
反应条件
1.1: n-butyllithium / tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide; hexane / 0.5 h / -60 °C
1.2: -20 - 20 °C
2.1: Jone's reagent / acetone / 0 - 4 °C
View Scheme
参考文献
Fu, Yu; Weng, Yue; Hong, Wen-Xu; Zhang, Qinghai
Synlett, 2011 , # 6 p. 809 - 812
反应条件
1: 85 percent / lithium amide / liquid ammonia; tetrahydrofuran
2: H2; quinoline / 5 percent Pd/BaSO4 / hexane / 24 h / 40 °C / 1034.3 Torr
3: 92 percent / hydrogen chloride / methanol / 3 h / 4 °C
View Scheme
参考文献
Tomida, Ichiro; Mayesawa, Tsuneaki
Bioscience, Biotechnology, and Biochemistry, 1992 , vol. 56, # 12 p. 1962 - 1965
反应条件
2: 98 percent / H+ / methanol
3: 97 percent / LiAlH4 / bis-(2-methoxy-ethyl) ether / 200 °C
View Scheme
参考文献
Singh, Arti A.; Zulkifli, Siti N.A.; Meyns, Michaela; Hayes, Patricia Y.; De Voss, James J.
Tetrahedron Asymmetry, 2011 , vol. 22, # 18-19 p. 1709 - 1719
