2-(6-溴己氧基)四氢-2H-吡喃合成路线 （共 75 条）
反应条件
1: 58 percent / Li2CuCl4 / tetrahydrofuran / 4 h / -78 °C
2: 70 percent / PDC / dimethylformamide / 18 h
3: 100 percent / 5percent HCl
View Scheme
参考文献
Hassarajani, S. A.; Mithran, S.; Mamdapur, V. R.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1995 , vol. 34, # 5 p. 429 - 431
反应条件
1: 1.) Mg / 1.) THF
2: 82 percent / methyl triphenoxyphosphonium iodide / hexamethylphosphoric acid triamide / 1 h / 75 °C
3: 50 percent / trimethylamine-N-oxide / CHCl3
4: 24 percent / NaOEt
5: KOH / methanol
6: (COCl)2
View Scheme
参考文献
Crombie, Leslie; Denman, Raymond
Tetrahedron Letters, 1984 , vol. 25, # 38 p. 4267 - 4270
反应条件
1: 85 percent / lithium amide / liquid ammonia; tetrahydrofuran
2: 72 percent / Na; ammonia / diethyl ether
View Scheme
参考文献
Canevet; Roeder; Vostrowsky; Bestmann
Chemische Berichte, 1980 , vol. 113, # 3 p. 1115 - 1120
反应条件
dilithium tetrachlorocuprate; magnesium
1) THF, 2) THF, -70 deg C to 20 deg C; Yield given. Multistep reaction;
参考文献
Cheskis, B. A.; Ivanova, N. M.; Moiseenkov, A. M.; Nefedov, O. M.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1990 , vol. 39, # 11 p. 2296 - 2300
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1990 , # 11 p. 2539 - 2544
反应条件
1: 1) LiNH2 / 1) NH3(l), 3 h; 2) abs THF, 20-25 deg C, 13 h.
2: 85 percent / LiAlH4, / bis-(2-methoxy-ethyl) ether / 11.5 h / Heating
3: 90 percent / pyridinium chlorochromate / CH2Cl2
4: 1) sodium bis(trimethylsilyl)amide / 1) abs. THF; 2) abs. THF
5: 70 percent / glacial acetic acid / Heating
View Scheme
参考文献
Kovalev, B. G.; Avdeeva, L. A.; Sorochinskaya, A. M.
Journal of Organic Chemistry USSR (English Translation), 1988 , vol. 24, # 4 p. 641 - 646
Zhurnal Organicheskoi Khimii, 1988 , vol. 24, # 4 p. 713 - 718
