2,6-二碘-4-硝基苯胺合成路线 （共 21 条）
反应条件
1.1: NaNO2; H2SO4 / 2 h / 0 °C 1.2: 66 percent / CuSO4*5H2O / ethanol / 2 h / Heating 2.1: SnCl2*2H2O; NaBH4 / ethanol / 0.33 h / Heating View Scheme
参考文献
Willgerodt; Arnold
Chemische Berichte, 1901 , vol. 34, p. 3349
反应条件
1: SnCl2; concentrated hydrochloric acid
2: chromic acid
View Scheme
参考文献
Willgerodt; Arnold
Chemische Berichte, 1901 , vol. 34, p. 3349
反应条件
1: 45 percent / bis(triphenylphosphine)palladium(II)dichloride; copper(II) acetate; diisopropylamine / 1 h / 20 °C
2: 78 percent / aq. KOH / methanol / 0.33 h
View Scheme
参考文献
Chimenti; Bolasco; Secci; Granese
Synthetic Communications, 2004 , vol. 34, # 14 p. 2549 - 2555
反应条件
1: 1.) sodium nitrite, concentrated sulfuric acid; 2.) Gattermann copper
2: 24 percent / copper powder
View Scheme
参考文献
Ozasa, Shigeru; Fujioka, Yasuhiro; Kikutake, Jun-ichiro; Ibuki, Eiichi
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 5 p. 1572 - 1581
反应条件
1: 1.) sodium nitrite, concentrated sulfuric acid; 2.) Gattermann copper
2: 24 percent / copper powder
3: 96 percent / activated iron, hydrogen chloride / benzene
View Scheme
参考文献
Ozasa, Shigeru; Fujioka, Yasuhiro; Kikutake, Jun-ichiro; Ibuki, Eiichi
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 5 p. 1572 - 1581
反应条件
1: 1.) sodium nitrite, concentrated sulfuric acid; 2.) Gattermann copper
2: 24 percent / copper powder
3: 96 percent / activated iron, hydrogen chloride / benzene
4: 1.) natrium nitrite, concetrated sulfuric acid; 2.) potassium iodide
View Scheme
参考文献
Ozasa, Shigeru; Fujioka, Yasuhiro; Kikutake, Jun-ichiro; Ibuki, Eiichi
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 5 p. 1572 - 1581
反应条件
1: With sulfuric acid; acetic acid; sodium nitrite
T=25°C;
2: With potassium iodide
T=85 - 90°C; Further stages.;
参考文献
Zhang, Xin; Chen, Zhijian; Wuerthner, Frank
Journal of the American Chemical Society, 2007 , vol. 129, # 16 p. 4886 - 4887
反应条件
ethanol; sulfuric acid; sodium nitrite
T=60 - 90°C; 3 h; Cooling with iceInert atmosphere;
参考文献
Goerl, Christian; Beck, Nadine; Kleiber, Katharina; Alt, Helmut G.
Journal of Molecular Catalysis A: Chemical, 2012 , vol. 352, p. 110 - 127
反应条件
sulfuric acid; sodium nitrite in ethanol; chloroform; acetic acid
参考文献
Merck and Co., Inc.
Patent: US5256777 A1, 1993 ;
反应条件
sulfuric acid; sodium nitrite in ethanol; acetic acid
参考文献
Merck and Co., Inc.
Patent: US5292879 A1, 1994 ;
