反应条件
1.1: N-ethyl-N,N-diisopropylamine; diphenyl phosphoryl azide / 6 h / Inert atmosphere; Reflux
2.1: N,N,N',N,-tetramethylethylenediamine; n-butyllithium / tetrahydrofuran / 2 h / -60 °C / Inert atmosphere
2.3: pH 2
3.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 2 h / 60 °C
3.2: 0 - 5 °C
View Scheme
参考文献
ABBOTT LABORATORIES; VASUDEVAN, Anil; PENNING, Thomas, Dale; CHEN, Huanming; LIANG, Bo; WANG, Shaohui; ZHAO, Zhongqiang; CHAI, Dikun; YANG, Leifu; GAO, Yingxiang
Patent: WO2012/97479 A1, 2012 ;
WO 2012/097479 A1
Title/Abstract Full Text Show Details
ABBOTT LABORATORIES; ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD.; VASUDEVAN, Anil; PENNING, Thomas Dale; CHEN, Huanming; LIANG, Bo; WANG, Shaohui; ZHAO, Zhongqiang; CHAI, Dikun; YANG, Leifu; GAO, Yingxiang
Patent: WO2012/97683 A1, 2012 ;